GO Annotations Graph

• Symbol: Ltf
• Name: lactotransferrin
• ID: MGI:96837

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:73065
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IDA	J:95253
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:113020
Cellular Component	GO:0005769	early endosome	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	ISO	J:73065
Cellular Component	GO:0042581	specific granule	ISO	J:164563
Biological Process	GO:0019731	antibacterial humoral response	ISO	J:164563
Biological Process	GO:0019731	antibacterial humoral response	IBA	J:265628
Biological Process	GO:0019732	antifungal humoral response	ISO	J:164563
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0060349	bone morphogenesis	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0052337	disruption by host of symbiont membrane	ISO	J:164563
Biological Process	GO:0052337	disruption by host of symbiont membrane	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0002227	innate immune response in mucosa	ISO	J:164563
Biological Process	GO:0006826	iron ion transport	IBA	J:265628
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0044793	negative regulation by host of viral process	ISO	J:164563
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	ISO	J:164563
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045837	negative regulation of membrane potential	ISO	J:164563
Biological Process	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	ISO	J:164563
Biological Process	GO:0045071	negative regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0048525	negative regulation of viral process	ISO	J:164563
Biological Process	GO:0001503	ossification	IEA	J:60000
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0001817	regulation of cytokine production	ISO	J:164563
Biological Process	GO:0032680	regulation of tumor necrosis factor production	ISO	J:164563