GO Annotations Graph

• Symbol: Mdk
• Name: midkine
• ID: MGI:96949

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035374	chondroitin sulfate binding	IDA	J:273528
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:1904399	heparan sulfate binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IDA	J:273528
Molecular Function	GO:0005515	protein binding	IPI	J:273581
Molecular Function	GO:0005515	protein binding	IPI	J:117275
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Biological Process	GO:0030325	adrenal gland development	ISO	J:155856
Biological Process	GO:0001662	behavioral fear response	IMP	J:76278
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0021681	cerebellar granular layer development	IMP	J:76278
Biological Process	GO:0021987	cerebral cortex development	IEP	J:76278
Biological Process	GO:0007010	cytoskeleton organization	IMP	J:117275
Biological Process	GO:0030421	defecation	IMP	J:76278
Biological Process	GO:0021542	dentate gyrus development	IEP	J:76278
Biological Process	GO:0044849	estrous cycle	IMP	J:123392
Biological Process	GO:0106091	glial cell projection elongation	IDA	J:117275
Biological Process	GO:0021766	hippocampus development	IMP	J:76278
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	IMP	J:60666
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	IMP	J:102069
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:172537
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:146315
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:126406
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0007162	negative regulation of cell adhesion	IDA	J:273528
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IMP	J:93637
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	IMP	J:126406
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:147025
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:170049
Biological Process	GO:1901215	negative regulation of neuron death	IDA	J:170049
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:233132
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	ISO	J:164563
Biological Process	GO:0048477	oogenesis	IMP	J:123392
Biological Process	GO:1905653	positive regulation of artery morphogenesis	IMP	J:269128
Biological Process	GO:1905555	positive regulation of blood vessel branching	ISO	J:164563
Biological Process	GO:0061036	positive regulation of cartilage development	IMP	J:225370
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:76278
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	IMP	J:102069
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0106016	positive regulation of inflammatory response to wounding	IMP	J:241140
Biological Process	GO:0106016	positive regulation of inflammatory response to wounding	IMP	J:209651
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	ISO	J:164563
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	IMP	J:209651
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	IMP	J:102069
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	IMP	J:241140
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IMP	J:60666
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:147025
Biological Process	GO:2001224	positive regulation of neuron migration	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	IMP	J:93637
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	IMP	J:209651
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:164563
Biological Process	GO:0071673	positive regulation of smooth muscle cell chemotaxis	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IMP	J:117275
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:241140
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	IMP	J:269128
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0050795	regulation of behavior	IMP	J:76278
Biological Process	GO:0046850	regulation of bone remodeling	IMP	J:172537
Biological Process	GO:0032330	regulation of chondrocyte differentiation	IMP	J:225370
Biological Process	GO:0010996	response to auditory stimulus	IMP	J:110520
Biological Process	GO:0009611	response to wounding	IDA	J:60666
Biological Process	GO:0009611	response to wounding	ISO	J:155856
Biological Process	GO:0007614	short-term memory	IMP	J:76278
Biological Process	GO:0002286	T cell activation involved in immune response	IMP	J:241140
Biological Process	GO:0042246	tissue regeneration	IMP	J:102069