GO Annotations Graph

• Symbol: Mif
• Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
• ID: MGI:96982

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:157889
Molecular Function	GO:0005125	cytokine activity	IDA	J:114878
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005126	cytokine receptor binding	ISO	J:164563
Molecular Function	GO:0004167	dopachrome isomerase activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0050178	phenylpyruvate tautomerase activity	IBA	J:265628
Molecular Function	GO:0050178	phenylpyruvate tautomerase activity	ISO	J:73065
Molecular Function	GO:0050178	phenylpyruvate tautomerase activity	IMP	J:103661
Molecular Function	GO:0002020	protease binding	IPI	J:175599
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:175599
Cellular Component	GO:0005615	extracellular space	IDA	J:73706
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0019752	carboxylic acid metabolic process	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IMP	J:84791
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	IMP	J:84791
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:114878
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	J:114878
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:164563
Biological Process	GO:0010760	negative regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0002906	negative regulation of mature B cell apoptotic process	IDA	J:131317
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	IMP	J:73706
Biological Process	GO:0051248	negative regulation of protein metabolic process	IDA	J:73706
Biological Process	GO:0002821	positive regulation of adaptive immune response	NAS	J:131317
Biological Process	GO:0090238	positive regulation of arachidonic acid secretion	IDA	J:157889
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA	J:131317
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:157889
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:114878
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IDA	J:157889
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IMP	J:73706
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:157889
Biological Process	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	IMP	J:73706
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:114878
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:114878
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0061078	positive regulation of prostaglandin secretion involved in immune response	IMP	J:73706
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:157889
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0070207	protein homotrimerization	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:84791