GO Annotations Graph

• Symbol: Kmt2a
• Name: lysine (K)-specific methyltransferase 2A
• ID: MGI:96995

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:96252
Molecular Function	GO:0003682	chromatin binding	IDA	J:96252
Molecular Function	GO:0003677	DNA binding	IDA	J:215255
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	IMP	J:215875
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	IDA	J:80575
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	ISO	J:164563
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	IBA	J:265628
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	IMP	J:221335
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	IMP	J:109102
Molecular Function	GO:0140945	histone H3K4 monomethyltransferase activity	IEA	J:72245
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0070577	lysine-acetylated histone binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:215875
Molecular Function	GO:0005515	protein binding	IPI	J:109102
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0106363	protein-cysteine methyltransferase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0045322	unmethylated CpG binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0035097	histone methyltransferase complex	ISO	J:164563
Cellular Component	GO:0035097	histone methyltransferase complex	IBA	J:265628
Cellular Component	GO:0071339	MLL1 complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:109102
Cellular Component	GO:0005634	nucleus	IDA	J:71817
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:96358
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:109102
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:215875
Biological Process	GO:0050890	cognition	IMP	J:221335
Biological Process	GO:0060216	definitive hemopoiesis	IMP	J:219101
Biological Process	GO:0006306	DNA methylation	IMP	J:109102
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:48502
Biological Process	GO:0035640	exploration behavior	IMP	J:221335
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:96252
Biological Process	GO:0051568	histone H3-K4 methylation	IBA	J:265628
Biological Process	GO:0080182	histone H3-K4 trimethylation	ISO	J:164563
Biological Process	GO:0016570	histone modification	ISO	J:164563
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IGI	J:189096
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:1905642	negative regulation of DNA methylation	ISO	J:164563
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	IMP	J:96252
Biological Process	GO:0018026	peptidyl-lysine monomethylation	IMP	J:221335
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:215875
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:80575
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:96252
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:96252
Biological Process	GO:0032411	positive regulation of transporter activity	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IGI	J:189096
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:221335
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	IMP	J:221335
Biological Process	GO:0009416	response to light stimulus	IMP	J:221335
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0048536	spleen development	IGI	J:189096
Biological Process	GO:0045064	T-helper 2 cell differentiation	ISO	J:164563
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563
Biological Process	GO:0008542	visual learning	IMP	J:221335