GO Annotations Graph

• Symbol: Mmp12
• Name: matrix metallopeptidase 12
• ID: MGI:97005

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2533953
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:213232
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:213232
Biological Process	GO:0060435	bronchiole development	IMP	J:89578
Biological Process	GO:0060435	bronchiole development	IMP	J:89578
Biological Process	GO:0060435	bronchiole development	IDA	J:89578
Biological Process	GO:0098586	cellular response to virus	IMP	J:213232
Biological Process	GO:0030574	collagen catabolic process	IBA	J:265628
Biological Process	GO:0060309	elastin catabolic process	ISO	J:164563
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0048286	lung alveolus development	IMP	J:89578
Biological Process	GO:1904905	negative regulation of endothelial cell-matrix adhesion via fibronectin	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:213232
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	IMP	J:213232
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:213232
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:213232
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	IMP	J:213232
Biological Process	GO:0006606	protein import into nucleus	IMP	J:213232
Biological Process	GO:0006606	protein import into nucleus	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0050691	regulation of defense response to virus by host	IMP	J:213232
Biological Process	GO:1901163	regulation of trophoblast cell migration	ISO	J:155856
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	ISO	J:164563