GO Annotations Graph

• Symbol: Mmp9
• Name: matrix metallopeptidase 9
• ID: MGI:97011

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:304575
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:102661
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:42729
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:87629
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:73065
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:155856
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:155856
Molecular Function	GO:0008233	peptidase activity	IDA	J:100747
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0031012	extracellular matrix	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IMP	J:100747
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:0071460	cellular response to cell-matrix adhesion	ISO	J:155856
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0071492	cellular response to UV-A	ISO	J:164563
Biological Process	GO:0030574	collagen catabolic process	ISO	J:155856
Biological Process	GO:0030574	collagen catabolic process	IBA	J:265628
Biological Process	GO:0030574	collagen catabolic process	IDA	J:42729
Biological Process	GO:0007566	embryo implantation	IDA	J:140260
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0030198	extracellular matrix organization	IGI	J:100747
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:100747
Biological Process	GO:0007507	heart development	ISO	J:155856
Biological Process	GO:0050900	leukocyte migration	IEA	J:72247
Biological Process	GO:0048246	macrophage chemotaxis	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2001258	negative regulation of cation channel activity	ISO	J:164563
Biological Process	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2000697	negative regulation of epithelial cell differentiation involved in kidney development	IDA	J:268011
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0001503	ossification	IEA	J:72247
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:100747
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051549	positive regulation of keratinocyte migration	ISO	J:164563
Biological Process	GO:0002687	positive regulation of leukocyte migration	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:1900122	positive regulation of receptor binding	ISO	J:164563
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0031915	positive regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:1904645	response to amyloid-beta	IDA	J:273538
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0001501	skeletal system development	IMP	J:100747
Biological Process	GO:0001501	skeletal system development	IGI	J:100747
Biological Process	GO:0048771	tissue remodeling	ISO	J:155856