GO Annotations Graph

• Symbol: Msx2
• Name: msh homeobox 2
• ID: MGI:97169

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:42570
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:196266
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	J:32834
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:32834
Molecular Function	GO:0005515	protein binding	IPI	J:143687
Molecular Function	GO:0005515	protein binding	IPI	J:77266
Molecular Function	GO:0005515	protein binding	IPI	J:67230
Molecular Function	GO:0005515	protein binding	IPI	J:64918
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	J:32834
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:73065
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:94905
Molecular Function	GO:0008134	transcription factor binding	IPI	J:42570
Molecular Function	GO:0008134	transcription factor binding	IDA	J:42570
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007762
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Biological Process	GO:0090427	activation of meiosis	IPI	J:178676
Biological Process	GO:0042640	anagen	IMP	J:73670
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:139946
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:138713
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:124119
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	IGI	J:139946
Biological Process	GO:0060349	bone morphogenesis	IGI	J:125119
Biological Process	GO:0060346	bone trabecula formation	IMP	J:61509
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:61509
Biological Process	GO:0051216	cartilage development	ISO	J:155856
Biological Process	GO:0051216	cartilage development	IMP	J:71946
Biological Process	GO:0051216	cartilage development	IMP	J:61509
Biological Process	GO:0042637	catagen	IMP	J:61509
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:35807
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:21055
Biological Process	GO:0002063	chondrocyte development	IMP	J:61509
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:150759
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:98917
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:150759
Biological Process	GO:0048598	embryonic morphogenesis	IBA	J:265628
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IGI	J:171190
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IGI	J:171190
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IGI	J:171190
Biological Process	GO:0070166	enamel mineralization	IMP	J:61509
Biological Process	GO:0070166	enamel mineralization	IMP	J:61509
Biological Process	GO:0003416	endochondral bone growth	IMP	J:61509
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IGI	J:139946
Biological Process	GO:0060364	frontal suture morphogenesis	IMP	J:61509
Biological Process	GO:0061180	mammary gland epithelium development	IGI	J:61509
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:124119
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:124119
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IDA	J:91833
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:94905
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:91833
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	IMP	J:167662
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:32834
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:196266
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:161903
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:117610
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:42570
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IDA	J:196266
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IDA	J:91833
Biological Process	GO:0042476	odontogenesis	IMP	J:61509
Biological Process	GO:0001503	ossification	IMP	J:61509
Biological Process	GO:0002076	osteoblast development	IMP	J:61509
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:94905
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:124119
Biological Process	GO:0003148	outflow tract septum morphogenesis	IGI	J:124119
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IGI	J:139946
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:2001055	positive regulation of mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:2001055	positive regulation of mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA	J:91833
Biological Process	GO:0051795	positive regulation of timing of catagen	IMP	J:61509
Biological Process	GO:0042981	regulation of apoptotic process	IDA	J:138805
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IGI	J:171190
Biological Process	GO:0048863	stem cell differentiation	IGI	J:125119
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0042060	wound healing	IMP	J:167662
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	IMP	J:167662