GO Annotations Graph

• Symbol: Mt3
• Name: metallothionein 3
• ID: MGI:97173

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046870	cadmium ion binding	ISO	J:164563
Molecular Function	GO:0005507	copper ion binding	ISO	J:155856
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IDA	J:79346
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IDA	J:20805
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0097450	astrocyte end-foot	ISO	J:155856
Cellular Component	GO:0097449	astrocyte projection	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-6798571
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0005840	ribosome	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:20805
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0014002	astrocyte development	IDA	J:168048
Biological Process	GO:0044242	cellular lipid catabolic process	IMP	J:168048
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:0071280	cellular response to copper ion	IBA	J:265628
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:168048
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0006707	cholesterol catabolic process	IMP	J:168048
Biological Process	GO:0071585	detoxification of cadmium ion	IMP	J:182479
Biological Process	GO:0006112	energy reserve metabolic process	IMP	J:178564
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0016570	histone modification	ISO	J:164563
Biological Process	GO:0030003	intracellular monoatomic cation homeostasis	IDA	J:79346
Biological Process	GO:0006882	intracellular zinc ion homeostasis	IDA	J:182374
Biological Process	GO:0006882	intracellular zinc ion homeostasis	IMP	J:178564
Biological Process	GO:0006882	intracellular zinc ion homeostasis	IDA	J:168048
Biological Process	GO:0033210	leptin-mediated signaling pathway	IMP	J:178564
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:157210
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:168048
Biological Process	GO:0030517	negative regulation of axon extension	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:168048
Biological Process	GO:2000296	negative regulation of hydrogen peroxide catabolic process	ISO	J:155856
Biological Process	GO:0060547	negative regulation of necrotic cell death	ISO	J:164563
Biological Process	GO:0060547	negative regulation of necrotic cell death	IMP	J:182479
Biological Process	GO:0050768	negative regulation of neurogenesis	IDA	J:79346
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:182374
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0051354	negative regulation of oxidoreductase activity	ISO	J:164563
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0043085	positive regulation of catalytic activity	IMP	J:168048
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	IMP	J:168048
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:178564
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:178564
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:168048
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0097214	positive regulation of lysosomal membrane permeability	IMP	J:168048
Biological Process	GO:0010940	positive regulation of necrotic cell death	ISO	J:164563
Biological Process	GO:2000376	positive regulation of oxygen metabolic process	IMP	J:178564
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0060049	regulation of protein glycosylation	IMP	J:168048
Biological Process	GO:0032095	regulation of response to food	IMP	J:178564
Biological Process	GO:0019430	removal of superoxide radicals	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	IMP	J:157210
Biological Process	GO:0051238	sequestering of metal ion	IMP	J:182479
Biological Process	GO:0006829	zinc ion transport	IDA	J:182374