GO Annotations Graph

• Symbol: Casp2
• Name: caspase 2
• ID: MGI:97295

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:101402
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA	J:265628
Molecular Function	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	IEA	J:72247
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	RCA	J:84168
Molecular Function	GO:0005515	protein binding	IPI	J:81904
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Cellular Component	GO:0008303	caspase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	NAS	J:246097
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:63729
Cellular Component	GO:1905369	endopeptidase complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	NAS	J:246097
Cellular Component	GO:0005634	nucleus	IDA	J:81904
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IBA	J:265628
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:101402
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:81904
Biological Process	GO:0006974	DNA damage response	NAS	J:320335
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO	J:164563
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:115619
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:115619
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:20338
Biological Process	GO:0060546	negative regulation of necroptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:81904
Biological Process	GO:0043065	positive regulation of apoptotic process	NAS	J:320335
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:20338
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:101402
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	RCA	J:84168
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0097752	regulation of DNA stability	IDA	J:204798
Biological Process	GO:0001836	release of cytochrome c from mitochondria	ISO	J:164563