GO Annotations Graph

• Symbol: Ngf
• Name: nerve growth factor
• ID: MGI:97321

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0038177	death receptor agonist activity	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0005163	nerve growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005163	nerve growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0005102	signaling receptor binding	IEA	J:72247
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IDA	J:184958
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IDA	J:237361
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181822
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-194544
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-198263
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-198275
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-204967
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-205060
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-205099
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0008021	synaptic vesicle	IBA	J:265628
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0008344	adult locomotory behavior	ISO	J:155856
Biological Process	GO:0048675	axon extension	IMP	J:32557
Biological Process	GO:0048675	axon extension	IMP	J:32557
Biological Process	GO:0071229	cellular response to acid chemical	IDA	J:219199
Biological Process	GO:0007623	circadian rhythm	IEP	J:199564
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:86711
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0007613	memory	IBA	J:265628
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IBA	J:265628
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:207835
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:72722
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	ISO	J:155856
Biological Process	GO:0021675	nerve development	IBA	J:265628
Biological Process	GO:0038180	nerve growth factor signaling pathway	IBA	J:265628
Biological Process	GO:0038180	nerve growth factor signaling pathway	IGI	J:207835
Biological Process	GO:0038180	nerve growth factor signaling pathway	IGI	J:207835
Biological Process	GO:0038180	nerve growth factor signaling pathway	IDA	J:21389
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:207835
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:86711
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:72722
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	IDA	J:237361
Biological Process	GO:0048812	neuron projection morphogenesis	IBA	J:265628
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:124964
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:87702
Biological Process	GO:0045773	positive regulation of axon extension	IDA	J:130448
Biological Process	GO:0045773	positive regulation of axon extension	IMP	J:32557
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0048672	positive regulation of collateral sprouting	IBA	J:265628
Biological Process	GO:0048672	positive regulation of collateral sprouting	IDA	J:130448
Biological Process	GO:0043388	positive regulation of DNA binding	IMP	J:255603
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:145554
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:255603
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:213126
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0014042	positive regulation of neuron maturation	IGI	J:188272
Biological Process	GO:0014042	positive regulation of neuron maturation	IGI	J:188272
Biological Process	GO:0014042	positive regulation of neuron maturation	IGI	J:188272
Biological Process	GO:0014042	positive regulation of neuron maturation	IDA	J:188272
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:76551
Biological Process	GO:0010976	positive regulation of neuron projection development	IDA	J:188272
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:188272
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:188272
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:188272
Biological Process	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	ISO	J:145554
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:145554
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:184958
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:184958
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:184958
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:237361
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:210609
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	IDA	J:76551
Biological Process	GO:2000648	positive regulation of stem cell proliferation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:237361
Biological Process	GO:0045664	regulation of neuron differentiation	IBA	J:265628
Biological Process	GO:0045664	regulation of neuron differentiation	IDA	J:107643
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IGI	J:104588
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IGI	J:207839
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	IMP	J:17792
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628