GO Annotations Graph

• Symbol: Ngfr
• Name: nerve growth factor receptor (TNFR superfamily, member 16)
• ID: MGI:97323

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	IBA	J:265628
Molecular Function	GO:0005035	death receptor activity	ISO	J:164563
Molecular Function	GO:0005035	death receptor activity	IBA	J:265628
Molecular Function	GO:0005035	death receptor activity	IDA	J:62753
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0048406	nerve growth factor binding	ISO	J:155856
Molecular Function	GO:0048406	nerve growth factor binding	IBA	J:265628
Molecular Function	GO:0048406	nerve growth factor binding	IDA	J:43748
Molecular Function	GO:0043121	neurotrophin binding	ISO	J:155856
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	ISO	J:155856
Molecular Function	GO:0070678	preprotein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:66924
Molecular Function	GO:0005515	protein binding	IPI	J:98749
Molecular Function	GO:0005515	protein binding	IPI	J:214739
Molecular Function	GO:0005515	protein binding	IPI	J:100024
Molecular Function	GO:0005515	protein binding	IPI	J:100024
Molecular Function	GO:0005515	protein binding	IPI	J:100024
Molecular Function	GO:0005515	protein binding	IPI	J:73942
Molecular Function	GO:0005515	protein binding	IPI	J:100024
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	IDA	J:183530
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IDA	J:52794
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	IDA	J:171468
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle	ISO	J:155856
Cellular Component	GO:0030135	coated vesicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:150519
Cellular Component	GO:0005737	cytoplasm	IDA	J:218609
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:293431
Cellular Component	GO:0031594	neuromuscular junction	IMP	J:293431
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-194544
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-204967
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-205060
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-205099
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:57952
Cellular Component	GO:0014069	postsynaptic density	IDA	J:207532
Cellular Component	GO:0098793	presynapse	IMP	J:293431
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007411	axon guidance	IMP	J:76254
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:155856
Biological Process	GO:0007417	central nervous system development	IMP	J:76254
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:199564
Biological Process	GO:0007623	circadian rhythm	IEP	J:199564
Biological Process	GO:0016048	detection of temperature stimulus	IMP	J:43748
Biological Process	GO:0035907	dorsal aorta development	IMP	J:71955
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP	J:58865
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP	J:58865
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:58865
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:58865
Biological Process	GO:0042593	glucose homeostasis	IMP	J:183530
Biological Process	GO:0001942	hair follicle development	IMP	J:58865
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:58865
Biological Process	GO:0001678	intracellular glucose homeostasis	IMP	J:183530
Biological Process	GO:0006886	intracellular protein transport	IMP	J:183530
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0061000	negative regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	IMP	J:58865
Biological Process	GO:0051799	negative regulation of hair follicle development	IMP	J:58865
Biological Process	GO:0051902	negative regulation of mitochondrial depolarization	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0021675	nerve development	IMP	J:43748
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:164563
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:42087
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IDA	J:62753
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:58865
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0031643	positive regulation of myelination	ISO	J:155856
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0042488	positive regulation of odontogenesis of dentin-containing tooth	IMP	J:42087
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ISO	J:155856
Biological Process	GO:0032224	positive regulation of synaptic transmission, cholinergic	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:293431
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:293431
Biological Process	GO:0010941	regulation of cell death	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:58865
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0009611	response to wounding	ISO	J:155856
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0043588	skin development	IMP	J:43748