Nkx2-2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nkx2-2
NK2 homeobox 2
MGI:97347

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:156329
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:156329
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:88815
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:86307
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:88815
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:119914
Molecular Function	GO:0005515	protein binding	IPI	J:86307
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:88815
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:88815
Molecular Function	GO:0008134	transcription factor binding	IPI	J:119284
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:105207
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:104307
Cellular Component	GO:0005634	nucleus	IDA	J:41620
Cellular Component	GO:0005634	nucleus	IDA	J:86307
Cellular Component	GO:0005634	nucleus	IDA	J:130846
Biological Process	GO:0048708	astrocyte differentiation	IMP	J:147382
Biological Process	GO:0048468	cell development	IMP	J:97013
Biological Process	GO:0048468	cell development	IMP	J:97013
Biological Process	GO:0048468	cell development	IMP	J:97013
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IMP	J:88639
Biological Process	GO:0048565	digestive tract development	IMP	J:145575
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:48576
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045665	negative regulation of neuron differentiation	IDA	J:133641
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:54240
Biological Process	GO:0007399	nervous system development	IDA	J:86307
Biological Process	GO:0061101	neuroendocrine cell differentiation	IMP	J:145575
Biological Process	GO:0030182	neuron differentiation	IDA	J:133641
Biological Process	GO:0030182	neuron differentiation	IMP	J:54240
Biological Process	GO:0030182	neuron differentiation	IMP	J:54240
Biological Process	GO:0030182	neuron differentiation	IDA	J:133641
Biological Process	GO:0030182	neuron differentiation	IMP	J:54240
Biological Process	GO:0048665	neuron fate specification	IGI	J:104370
Biological Process	GO:0048665	neuron fate specification	IMP	J:152847
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:97013
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:71636
Biological Process	GO:0003326	pancreatic A cell fate commitment	IGI	J:129103
Biological Process	GO:0003326	pancreatic A cell fate commitment	IMP	J:119914
Biological Process	GO:0003329	pancreatic PP cell fate commitment	IGI	J:129103
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	IMP	J:87406
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:201967
Biological Process	GO:0045666	positive regulation of neuron differentiation	IMP	J:54240
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:133641
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:71636
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:88815
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:97013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:97013
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:86307
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:138713
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IMP	J:54240
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	IGI	J:135661
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	IMP	J:97013
Biological Process	GO:0021530	spinal cord oligodendrocyte cell fate specification	IDA	J:135661
Biological Process	GO:0003323	type B pancreatic cell development	IDA	J:126460
Biological Process	GO:0003323	type B pancreatic cell development	IMP	J:119914
Biological Process	GO:0003309	type B pancreatic cell differentiation	IMP	J:87406
Biological Process	GO:0003327	type B pancreatic cell fate commitment	IMP	J:129103
Biological Process	GO:0003327	type B pancreatic cell fate commitment	IMP	J:119914
Biological Process	GO:0060580	ventral spinal cord interneuron fate determination	IMP	J:54240

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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