Nkx2-5 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nkx2-5
NK2 homeobox 5
MGI:97350

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:150360
Molecular Function	GO:0003682	chromatin binding	IDA	J:150360
Molecular Function	GO:0003682	chromatin binding	ISO	J:73065
Molecular Function	GO:0003682	chromatin binding	IDA	J:150360
Molecular Function	GO:0003682	chromatin binding	IDA	J:150360
Molecular Function	GO:0003682	chromatin binding	IDA	J:171727
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:148078
Molecular Function	GO:0003677	DNA binding	IDA	J:84692
Molecular Function	GO:0003677	DNA binding	IDA	J:79153
Molecular Function	GO:0003677	DNA binding	IDA	J:93034
Molecular Function	GO:0003677	DNA binding	IDA	J:36916
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:93034
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:151625
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:71845
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:131435
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:36916
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:171727
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:115868
Molecular Function	GO:0005515	protein binding	IPI	J:50387
Molecular Function	GO:0005515	protein binding	IPI	J:113930
Molecular Function	GO:0005515	protein binding	IPI	J:113930
Molecular Function	GO:0005515	protein binding	IPI	J:175199
Molecular Function	GO:0005515	protein binding	IPI	J:36110
Molecular Function	GO:0005515	protein binding	IPI	J:124772
Molecular Function	GO:0005515	protein binding	IPI	J:166035
Molecular Function	GO:0005515	protein binding	IPI	J:150360
Molecular Function	GO:0005515	protein binding	IPI	J:95125
Molecular Function	GO:0005515	protein binding	IPI	J:180125
Molecular Function	GO:0005515	protein binding	IPI	J:71845
Molecular Function	GO:0005515	protein binding	IPI	J:76656
Molecular Function	GO:0005515	protein binding	IPI	J:93034
Molecular Function	GO:0005515	protein binding	IPI	J:201868
Molecular Function	GO:0005515	protein binding	IPI	J:102644
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:148078
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:36110
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:143686
Cellular Component	GO:0005634	nucleus	IDA	J:175199
Cellular Component	GO:0005634	nucleus	IDA	J:143686
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:177922
Cellular Component	GO:0005634	nucleus	IDA	J:204470
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:76656
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Biological Process	GO:0007512	adult heart development	ISO	J:164563
Biological Process	GO:0007512	adult heart development	IMP	J:27443
Biological Process	GO:0006915	apoptotic process	IGI	J:69976
Biological Process	GO:0003278	apoptotic process involved in heart morphogenesis	IMP	J:131435
Biological Process	GO:0055014	atrial cardiac muscle cell development	TAS	J:48404
Biological Process	GO:0003228	atrial cardiac muscle tissue development	IMP	J:133688
Biological Process	GO:0060413	atrial septum morphogenesis	ISO	J:164563
Biological Process	GO:0060928	atrioventricular node cell development	IMP	J:151895
Biological Process	GO:0060929	atrioventricular node cell fate commitment	IMP	J:89404
Biological Process	GO:0003162	atrioventricular node development	IMP	J:143802
Biological Process	GO:0003166	bundle of His development	IGI	J:122971
Biological Process	GO:0003161	cardiac conduction system development	ISO	J:73065
Biological Process	GO:0003161	cardiac conduction system development	IGI	J:174208
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:146147
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:175381
Biological Process	GO:0055007	cardiac muscle cell differentiation	IDA	J:175128
Biological Process	GO:0055007	cardiac muscle cell differentiation	IGI	J:142102
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:52597
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:133688
Biological Process	GO:0060038	cardiac muscle cell proliferation	IGI	J:185712
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:151895
Biological Process	GO:0048738	cardiac muscle tissue development	IMP	J:27443
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	IMP	J:175381
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	ISO	J:164563
Biological Process	GO:0003211	cardiac ventricle formation	IGI	J:142102
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:131435
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IGI	J:69976
Biological Process	GO:0035050	embryonic heart tube development	IGI	J:98489
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	IMP	J:41048
Biological Process	GO:0007492	endoderm development	TAS	J:48404
Biological Process	GO:1904019	epithelial cell apoptotic process	IGI	J:69976
Biological Process	GO:0030855	epithelial cell differentiation	IGI	J:69976
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:69976
Biological Process	GO:0060047	heart contraction	IGI	J:174208
Biological Process	GO:0007507	heart development	IMP	J:89216
Biological Process	GO:0007507	heart development	IMP	J:89216
Biological Process	GO:0007507	heart development	IMP	J:52597
Biological Process	GO:0007507	heart development	IGI	J:69976
Biological Process	GO:0001947	heart looping	IMP	J:131435
Biological Process	GO:0001947	heart looping	IMP	J:41048
Biological Process	GO:0001947	heart looping	IMP	J:27443
Biological Process	GO:0003007	heart morphogenesis	IMP	J:133688
Biological Process	GO:0003007	heart morphogenesis	IMP	J:72600
Biological Process	GO:0060347	heart trabecula formation	IMP	J:131435
Biological Process	GO:0030097	hemopoiesis	IMP	J:52597
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:149314
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:134004
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IGI	J:69976
Biological Process	GO:0010832	negative regulation of myotube differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:150360
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:76656
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:131435
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:142102
Biological Process	GO:0003148	outflow tract septum morphogenesis	ISO	J:164563
Biological Process	GO:0060037	pharyngeal system development	IGI	J:69976
Biological Process	GO:0051891	positive regulation of cardioblast differentiation	IMP	J:134004
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:89500
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:71845
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IGI	J:69976
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:175128
Biological Process	GO:0045823	positive regulation of heart contraction	IMP	J:143802
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0010765	positive regulation of sodium ion transport	IMP	J:143802
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:143802
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:151625
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:102644
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:36916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:107397
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:177922
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:131435
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:105332
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:122971
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:93034
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	IDA	J:36110
Biological Process	GO:0003342	proepicardium development	IMP	J:141020
Biological Process	GO:0003350	pulmonary myocardium development	IMP	J:141338
Biological Process	GO:0003168	Purkinje myocyte differentiation	IMP	J:134434
Biological Process	GO:1903779	regulation of cardiac conduction	IMP	J:143802
Biological Process	GO:0060043	regulation of cardiac muscle cell proliferation	IDA	J:163662
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IMP	J:143802
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:86864
Biological Process	GO:0003221	right ventricular cardiac muscle tissue morphogenesis	ISO	J:164563
Biological Process	GO:0003285	septum secundum development	ISO	J:164563
Biological Process	GO:0048536	spleen development	ISO	J:164563
Biological Process	GO:0048536	spleen development	TAS	J:48404
Biological Process	GO:0048536	spleen development	IGI	J:184521
Biological Process	GO:0048536	spleen development	IGI	J:184521
Biological Process	GO:0030878	thyroid gland development	IMP	J:143681
Biological Process	GO:0030878	thyroid gland development	ISO	J:164563
Biological Process	GO:0043586	tongue development	TAS	J:48404
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:122971
Biological Process	GO:0001570	vasculogenesis	IMP	J:52597
Biological Process	GO:0055015	ventricular cardiac muscle cell development	TAS	J:48404
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	IMP	J:151895
Biological Process	GO:0060412	ventricular septum morphogenesis	ISO	J:164563
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP	J:89404

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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