GO Annotations Graph

• Symbol: Nkx2-6
• Name: NK2 homeobox 6
• ID: MGI:97351

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IGI	J:69976
Biological Process	GO:0055014	atrial cardiac muscle cell development	IEP	J:48404
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IGI	J:69976
Biological Process	GO:0048565	digestive tract development	IEP	J:143700
Biological Process	GO:0035050	embryonic heart tube development	IEP	J:143700
Biological Process	GO:0035050	embryonic heart tube development	ISO	J:164563
Biological Process	GO:1904019	epithelial cell apoptotic process	IGI	J:69976
Biological Process	GO:0030855	epithelial cell differentiation	IGI	J:69976
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:69976
Biological Process	GO:0007507	heart development	IGI	J:69976
Biological Process	GO:0021854	hypothalamus development	IEP	J:48404
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IGI	J:69976
Biological Process	GO:0060039	pericardium development	IEP	J:143700
Biological Process	GO:0060037	pharyngeal system development	IEP	J:48404
Biological Process	GO:0060037	pharyngeal system development	IEP	J:143700
Biological Process	GO:0060037	pharyngeal system development	IEP	J:45685
Biological Process	GO:0060037	pharyngeal system development	IGI	J:69976
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IGI	J:69976
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0043586	tongue development	IEP	J:48404
Biological Process	GO:0055015	ventricular cardiac muscle cell development	IEP	J:48404