GO Annotations Graph

• Symbol: Nkx3-1
• Name: NK3 homeobox 1
• ID: MGI:97352

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:66243
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:177149
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:66243
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:177149
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0097162	MADS box domain binding	IDA	J:177149
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:139640
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:40046
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IDA	J:66243
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:101172
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0030521	androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	IMP	J:54465
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	IMP	J:64981
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	IMP	J:63764
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	IMP	J:64981
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:64981
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0035907	dorsal aorta development	IEP	J:40046
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:64981
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:74350
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:64981
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:74350
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:64981
Biological Process	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IMP	J:63764
Biological Process	GO:0007507	heart development	IEP	J:48404
Biological Process	GO:0035260	internal genitalia morphogenesis	TAS	J:48404
Biological Process	GO:0008584	male gonad development	IEP	J:40046
Biological Process	GO:0001656	metanephros development	IEP	J:40046
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:147094
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:153914
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:64981
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:64981
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	IMP	J:64981
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	IMP	J:74350
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	IDA	J:147094
Biological Process	GO:0060037	pharyngeal system development	IEP	J:48404
Biological Process	GO:2000836	positive regulation of androgen secretion	ISO	J:164563
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0051781	positive regulation of cell division	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:177149
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:66243
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0030850	prostate gland development	IEP	J:40046
Biological Process	GO:0030850	prostate gland development	TAS	J:48404
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:153914
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0032880	regulation of protein localization	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0033574	response to testosterone	IMP	J:40046
Biological Process	GO:0007431	salivary gland development	IMP	J:63764
Biological Process	GO:0001756	somitogenesis	IEP	J:48404
Biological Process	GO:0001655	urogenital system development	IEP	J:40046
Biological Process	GO:0001655	urogenital system development	TAS	J:48404