GO Annotations Graph

• Symbol: Nme1
• Name: NME/NM23 nucleoside diphosphate kinase 1
• ID: MGI:97355

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0004536	DNA nuclease activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0043015	gamma-tubulin binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019215	intermediate filament binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	ISO	J:155856
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	ISO	J:164563
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	IBA	J:265628
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	ISO	J:308108
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0043024	ribosomal small subunit binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005882	intermediate filament	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006241	CTP biosynthetic process	IEA	J:72247
Biological Process	GO:0006231	dTMP biosynthetic process	NAS	J:308061
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0006183	GTP biosynthetic process	IEA	J:72247
Biological Process	GO:0007595	lactation	IMP	J:109190
Biological Process	GO:0030879	mammary gland development	IMP	J:109190
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0002762	negative regulation of myeloid leukocyte differentiation	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0009117	nucleotide metabolic process	IEA	J:60000
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0006228	UTP biosynthetic process	IEA	J:72247