GO Annotations Graph

• Symbol: Nos1
• Name: nitric oxide synthase 1, neuronal
• ID: MGI:97360

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0046870	cadmium ion binding	ISO	J:155856
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0010181	FMN binding	ISO	J:155856
Molecular Function	GO:0010181	FMN binding	IBA	J:265628
Molecular Function	GO:0020037	heme binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0050661	NADP binding	ISO	J:155856
Molecular Function	GO:0070402	NADPH binding	ISO	J:155856
Molecular Function	GO:0004517	nitric-oxide synthase activity	ISO	J:164563
Molecular Function	GO:0004517	nitric-oxide synthase activity	ISO	J:155856
Molecular Function	GO:0004517	nitric-oxide synthase activity	IDA	J:139346
Molecular Function	GO:0004517	nitric-oxide synthase activity	IDA	J:212817
Molecular Function	GO:0004517	nitric-oxide synthase activity	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:130152
Molecular Function	GO:0005515	protein binding	IPI	J:139023
Molecular Function	GO:0005515	protein binding	IPI	J:139346
Molecular Function	GO:0005515	protein binding	IPI	J:121594
Molecular Function	GO:0005515	protein binding	IPI	J:217280
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0017080	sodium channel regulator activity	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0042582	azurophil granule	ISO	J:155856
Cellular Component	GO:0044305	calyx of Held	IMP	J:263442
Cellular Component	GO:0044305	calyx of Held	IDA	J:263442
Cellular Component	GO:0044305	calyx of Held	IMP	J:263442
Cellular Component	GO:0044305	calyx of Held	IDA	J:263442
Cellular Component	GO:0005901	caveola	IDA	J:217280
Cellular Component	GO:0071944	cell periphery	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IDA	J:139346
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IDA	J:53127
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:217280
Cellular Component	GO:0005739	mitochondrion	ISO	J:107662
Cellular Component	GO:0031965	nuclear membrane	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0001917	photoreceptor inner segment	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0099091	postsynaptic specialization, intracellular component	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:139346
Cellular Component	GO:0042383	sarcolemma	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:217280
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:76455
Cellular Component	GO:0030315	T-tubule	IDA	J:217280
Cellular Component	GO:0012506	vesicle membrane	ISO	J:155856
Cellular Component	GO:0012506	vesicle membrane	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:217280
Biological Process	GO:0006527	arginine catabolic process	ISO	J:155856
Biological Process	GO:0006527	arginine catabolic process	IBA	J:265628
Biological Process	GO:0048148	behavioral response to cocaine	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	IMP	J:113533
Biological Process	GO:0006816	calcium ion transport	IMP	J:113533
Biological Process	GO:0071872	cellular response to epinephrine stimulus	ISO	J:155856
Biological Process	GO:0071363	cellular response to growth factor stimulus	IMP	J:166020
Biological Process	GO:0071260	cellular response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:113533
Biological Process	GO:0045184	establishment of protein localization	ISO	J:155856
Biological Process	GO:0033555	multicellular organismal response to stress	ISO	J:164563
Biological Process	GO:0006936	muscle contraction	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0045776	negative regulation of blood pressure	IBA	J:265628
Biological Process	GO:0051926	negative regulation of calcium ion transport	IMP	J:113533
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0045822	negative regulation of heart contraction	ISO	J:155856
Biological Process	GO:0061875	negative regulation of hepatic stellate cell contraction	ISO	J:155856
Biological Process	GO:0051346	negative regulation of hydrolase activity	IMP	J:113533
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0034760	negative regulation of iron ion transmembrane transport	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0043267	negative regulation of potassium ion transport	IMP	J:113533
Biological Process	GO:0051612	negative regulation of serotonin uptake	IDA	J:121594
Biological Process	GO:0045906	negative regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0006809	nitric oxide biosynthetic process	IDA	J:212817
Biological Process	GO:0006809	nitric oxide biosynthetic process	IDA	J:139346
Biological Process	GO:0006809	nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0006809	nitric oxide biosynthetic process	IBA	J:265628
Biological Process	GO:0007263	nitric oxide mediated signal transduction	ISO	J:155856
Biological Process	GO:0007263	nitric oxide mediated signal transduction	IBA	J:265628
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	ISO	J:155856
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	IDA	J:125938
Biological Process	GO:0140196	positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	IMP	J:130152
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:166020
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	IBA	J:265628
Biological Process	GO:0035066	positive regulation of histone acetylation	IMP	J:166020
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1902307	positive regulation of sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0098735	positive regulation of the force of heart contraction	IMP	J:130152
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:86456
Biological Process	GO:0006813	potassium ion transport	IMP	J:113533
Biological Process	GO:0006813	potassium ion transport	IMP	J:113533
Biological Process	GO:0008016	regulation of heart contraction	ISO	J:155856
Biological Process	GO:0050767	regulation of neurogenesis	IDA	J:219183
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IMP	J:263442
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IDA	J:263442
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0002028	regulation of sodium ion transport	IMP	J:113533
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0009408	response to heat	ISO	J:164563
Biological Process	GO:0009725	response to hormone	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	IMP	J:174589
Biological Process	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	IBA	J:265628
Biological Process	GO:0006941	striated muscle contraction	IMP	J:107662
Biological Process	GO:0099163	synaptic signaling by nitric oxide	IMP	J:263442
Biological Process	GO:0099163	synaptic signaling by nitric oxide	IDA	J:263442
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042311	vasodilation	ISO	J:164563
Biological Process	GO:0042178	xenobiotic catabolic process	IMP	J:67775