Nos2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nos2
nitric oxide synthase 2, inducible
MGI:97361

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0034618	arginine binding	IDA	J:139344
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0045296	cadherin binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	TAS	J:113936
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IDA	J:139347
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0010181	FMN binding	IDA	J:139347
Molecular Function	GO:0010181	FMN binding	IBA	J:265628
Molecular Function	GO:0020037	heme binding	IDA	J:139347
Molecular Function	GO:0020037	heme binding	IDA	J:139344
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0050661	NADP binding	IEA	J:72247
Molecular Function	GO:0004517	nitric-oxide synthase activity	IDA	J:139344
Molecular Function	GO:0004517	nitric-oxide synthase activity	ISO	J:155856
Molecular Function	GO:0004517	nitric-oxide synthase activity	ISO	J:164563
Molecular Function	GO:0004517	nitric-oxide synthase activity	IDA	J:139347
Molecular Function	GO:0004517	nitric-oxide synthase activity	IBA	J:265628
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:171373
Molecular Function	GO:0005515	protein binding	IPI	J:113936
Molecular Function	GO:0005515	protein binding	IPI	J:113936
Molecular Function	GO:0005515	protein binding	IPI	J:162874
Molecular Function	GO:0005515	protein binding	IPI	J:169889
Molecular Function	GO:0005515	protein binding	IPI	J:168203
Molecular Function	GO:0005515	protein binding	IPI	J:85387
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:139344
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0034617	tetrahydrobiopterin binding	IDA	J:139344
Cellular Component	GO:0030863	cortical cytoskeleton	IDA	J:85387
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:85387
Cellular Component	GO:0005737	cytoplasm	IDA	J:74206
Cellular Component	GO:0005829	cytosol	TAS	J:113936
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:85387
Cellular Component	GO:0005777	peroxisome	ISO	J:155856
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0012506	vesicle membrane	ISO	J:155856
Cellular Component	GO:0012506	vesicle membrane	IBA	J:265628
Biological Process	GO:0006527	arginine catabolic process	IDA	J:139347
Biological Process	GO:0006527	arginine catabolic process	ISO	J:164563
Biological Process	GO:0006527	arginine catabolic process	IBA	J:265628
Biological Process	GO:0001974	blood vessel remodeling	ISO	J:155856
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:150450
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:155210
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:142604
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:150450
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:155210
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:219149
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:0007623	circadian rhythm	IEP	J:180997
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IBA	J:265628
Biological Process	GO:0042742	defense response to bacterium	IMP	J:85213
Biological Process	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	TAS	J:113936
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0045776	negative regulation of blood pressure	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IGI	J:183976
Biological Process	GO:0042177	negative regulation of protein catabolic process	IDA	J:169889
Biological Process	GO:0006809	nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0006809	nitric oxide biosynthetic process	IDA	J:139344
Biological Process	GO:0006809	nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0006809	nitric oxide biosynthetic process	IDA	J:139347
Biological Process	GO:0006809	nitric oxide biosynthetic process	IBA	J:265628
Biological Process	GO:0007263	nitric oxide mediated signal transduction	IBA	J:265628
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	IDA	J:168203
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	IBA	J:265628
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	ISO	J:164563
Biological Process	GO:0032310	prostaglandin secretion	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:73152
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:72030
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0008016	regulation of heart contraction	ISO	J:155856
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0009725	response to hormone	IBA	J:265628
Biological Process	GO:0001666	response to hypoxia	IDA	J:85387
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:180997
Biological Process	GO:0032496	response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:85213

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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