Nos3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0003785	actin monomer binding	ISO	J:164563
Molecular Function	GO:0034618	arginine binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0045296	cadherin binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0010181	FMN binding	IBA	J:265628
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0050661	NADP binding	IEA	J:72247
Molecular Function	GO:0004517	nitric-oxide synthase activity	ISO	J:155856
Molecular Function	GO:0004517	nitric-oxide synthase activity	ISO	J:164563
Molecular Function	GO:0004517	nitric-oxide synthase activity	IBA	J:265628
Molecular Function	GO:0004517	nitric-oxide synthase activity	IMP	J:97766
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:180208
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:215922
Molecular Function	GO:0034617	tetrahydrobiopterin binding	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IC	J:74206
Cellular Component	GO:0005737	cytoplasm	IDA	J:74206
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:74206
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0012506	vesicle membrane	ISO	J:155856
Cellular Component	GO:0012506	vesicle membrane	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:98913
Biological Process	GO:0003180	aortic valve morphogenesis	IGI	J:261833
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:261847
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:103340
Biological Process	GO:0006527	arginine catabolic process	ISO	J:164563
Biological Process	GO:0006527	arginine catabolic process	IBA	J:265628
Biological Process	GO:0097746	blood vessel diameter maintenance	IMP	J:119620
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:119620
Biological Process	GO:0006816	calcium ion transport	IMP	J:113533
Biological Process	GO:0006816	calcium ion transport	IMP	J:113533
Biological Process	GO:0071260	cellular response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:261833
Biological Process	GO:0043542	endothelial cell migration	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:113533
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IGI	J:261833
Biological Process	GO:0001701	in utero embryonic development	IMP	J:74206
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:97766
Biological Process	GO:0030324	lung development	IMP	J:98913
Biological Process	GO:0070168	negative regulation of biomineral tissue development	IMP	J:261847
Biological Process	GO:0045776	negative regulation of blood pressure	IBA	J:265628
Biological Process	GO:0051926	negative regulation of calcium ion transport	IMP	J:113533
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:119620
Biological Process	GO:0051346	negative regulation of hydrolase activity	IMP	J:113533
Biological Process	GO:0014740	negative regulation of muscle hyperplasia	IMP	J:119620
Biological Process	GO:0043267	negative regulation of potassium ion transport	IMP	J:113533
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IMP	J:162084
Biological Process	GO:0006809	nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0006809	nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0006809	nitric oxide biosynthetic process	IBA	J:265628
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:97766
Biological Process	GO:0007263	nitric oxide mediated signal transduction	IBA	J:265628
Biological Process	GO:0001542	ovulation from ovarian follicle	IMP	J:73964
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:139343
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:261847
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:261847
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	ISO	J:164563
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	IBA	J:265628
Biological Process	GO:0006813	potassium ion transport	IMP	J:113533
Biological Process	GO:0006813	potassium ion transport	IMP	J:113533
Biological Process	GO:0003184	pulmonary valve morphogenesis	IGI	J:261833
Biological Process	GO:0031644	regulation of nervous system process	IGI	J:268013
Biological Process	GO:0002028	regulation of sodium ion transport	IMP	J:113533
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	ISO	J:164563
Biological Process	GO:0003057	regulation of the force of heart contraction by chemical signal	IGI	J:144878
Biological Process	GO:0019430	removal of superoxide radicals	ISO	J:164563
Biological Process	GO:0032355	response to estradiol	ISO	J:155856
Biological Process	GO:0009725	response to hormone	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0014806	smooth muscle hyperplasia	IMP	J:119620
Biological Process	GO:0060412	ventricular septum morphogenesis	IGI	J:261833

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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