Notch2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Notch2
notch 2
MGI:97364

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	IPI	J:183220
Molecular Function	GO:0051059	NF-kappaB binding	IPI	J:140561
Molecular Function	GO:0005515	protein binding	IPI	J:58381
Molecular Function	GO:0005515	protein binding	IPI	J:115539
Molecular Function	GO:0005515	protein binding	IPI	J:88030
Molecular Function	GO:0005515	protein binding	IPI	J:320690
Molecular Function	GO:0005515	protein binding	IPI	J:40289
Molecular Function	GO:0005515	protein binding	IPI	J:320690
Molecular Function	GO:0005515	protein binding	IPI	J:320690
Molecular Function	GO:0005515	protein binding	IPI	J:320690
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:173367
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2197556
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2032378
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2032379
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2060798
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2193065
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2976706
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2976717
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2976723
Cellular Component	GO:0005634	nucleus	IDA	J:115539
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IC	J:58381
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2032378
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2032379
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2060798
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2193065
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-2197556
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:320690
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0032148	activation of protein kinase B activity	IDA	J:320690
Biological Process	GO:0009887	animal organ morphogenesis	TAS	J:115539
Biological Process	GO:0006915	apoptotic process	IEA	J:72247
Biological Process	GO:0060413	atrial septum morphogenesis	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:197419
Biological Process	GO:0046849	bone remodeling	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:72247
Biological Process	GO:0001709	cell fate determination	ISO	J:155856
Biological Process	GO:0001709	cell fate determination	TAS	J:115539
Biological Process	GO:0008283	cell population proliferation	IMP	J:197419
Biological Process	GO:0071228	cellular response to tumor cell	ISO	J:164563
Biological Process	GO:1990705	cholangiocyte proliferation	IMP	J:218171
Biological Process	GO:0061073	ciliary body morphogenesis	IMP	J:197419
Biological Process	GO:0042742	defense response to bacterium	IMP	J:208234
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:83358
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:103603
Biological Process	GO:0010001	glial cell differentiation	IBA	J:265628
Biological Process	GO:0072104	glomerular capillary formation	IEP	J:97734
Biological Process	GO:0001947	heart looping	IGI	J:83358
Biological Process	GO:0072574	hepatocyte proliferation	IMP	J:218171
Biological Process	GO:0006959	humoral immune response	IGI	J:123631
Biological Process	GO:0001701	in utero embryonic development	IMP	J:120082
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IGI	J:123631
Biological Process	GO:0032633	interleukin-4 production	IGI	J:123631
Biological Process	GO:0035622	intrahepatic bile duct development	IMP	J:218171
Biological Process	GO:0070986	left/right axis specification	IGI	J:83358
Biological Process	GO:0001889	liver development	IMP	J:218171
Biological Process	GO:0072576	liver morphogenesis	IMP	J:218171
Biological Process	GO:0002315	marginal zone B cell differentiation	IMP	J:146621
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	IMP	J:74574
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IMP	J:218171
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IMP	J:208234
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:197419
Biological Process	GO:0007219	Notch signaling pathway	IC	J:58381
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:320690
Biological Process	GO:0060674	placenta blood vessel development	IMP	J:120082
Biological Process	GO:0001890	placenta development	IMP	J:120082
Biological Process	GO:0072015	podocyte development	IEP	J:97734
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:103603
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:103603
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IMP	J:197419
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:197419
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	ISO	J:164563
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IBA	J:265628
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IDA	J:140561
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072014	proximal tubule development	IEP	J:97734
Biological Process	GO:0003184	pulmonary valve morphogenesis	ISO	J:164563
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0050793	regulation of developmental process	IEA	J:72247
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:2001204	regulation of osteoclast development	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:218171
Biological Process	GO:0042060	wound healing	IDA	J:115539

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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