GO Annotations Graph

• Symbol: Nppa
• Name: natriuretic peptide type A
• ID: MGI:97367

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0051427	hormone receptor binding	ISO	J:164563
Molecular Function	GO:0051427	hormone receptor binding	IBA	J:265628
Molecular Function	GO:0005184	neuropeptide hormone activity	ISO	J:164563
Molecular Function	GO:0071855	neuropeptide receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:298695
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0005903	brush border	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:84125
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:103584
Cellular Component	GO:0098690	glycinergic synapse	ISO	J:155856
Cellular Component	GO:0042629	mast cell granule	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IMP	J:103584
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IDA	J:211907
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IMP	J:102124
Biological Process	GO:0006182	cGMP biosynthetic process	ISO	J:155856
Biological Process	GO:0006182	cGMP biosynthetic process	ISO	J:164563
Biological Process	GO:0006182	cGMP biosynthetic process	IBA	J:265628
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:0019934	cGMP-mediated signaling	IBA	J:265628
Biological Process	GO:0007565	female pregnancy	IMP	J:183869
Biological Process	GO:0045776	negative regulation of blood pressure	IMP	J:198358
Biological Process	GO:0045776	negative regulation of blood pressure	IMP	J:237574
Biological Process	GO:0045776	negative regulation of blood pressure	IMP	J:310010
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:1903815	negative regulation of collecting lymphatic vessel constriction	ISO	J:155856
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043508	negative regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	IBA	J:265628
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	IBA	J:265628
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:1902261	positive regulation of delayed rectifier potassium channel activity	ISO	J:155856
Biological Process	GO:1902261	positive regulation of delayed rectifier potassium channel activity	ISO	J:164563
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:164563
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	ISO	J:155856
Biological Process	GO:1903766	positive regulation of potassium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:1903766	positive regulation of potassium ion export across plasma membrane	ISO	J:155856
Biological Process	GO:0006457	protein folding	ISO	J:164563
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	ISO	J:164563
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	IBA	J:265628
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	ISO	J:73065
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:183869
Biological Process	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:0036376	sodium ion export across plasma membrane	IMP	J:198358
Biological Process	GO:0099538	synaptic signaling via neuropeptide	ISO	J:155856
Biological Process	GO:0042311	vasodilation	IEA	J:60000