GO Annotations Graph

• Symbol: Nppb
• Name: natriuretic peptide type B
• ID: MGI:97368

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0051427	hormone receptor binding	ISO	J:164563
Molecular Function	GO:0051427	hormone receptor binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:298695
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:194542
Cellular Component	GO:0030133	transport vesicle	ISO	J:155856
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IDA	J:211907
Biological Process	GO:0006182	cGMP biosynthetic process	ISO	J:164563
Biological Process	GO:0006182	cGMP biosynthetic process	IBA	J:265628
Biological Process	GO:0019934	cGMP-mediated signaling	IBA	J:265628
Biological Process	GO:0060976	coronary vasculature development	IDA	J:298695
Biological Process	GO:0001935	endothelial cell proliferation	IDA	J:298695
Biological Process	GO:0048872	homeostasis of number of cells	IDA	J:298695
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	IDA	J:298695
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:1904055	negative regulation of cholangiocyte proliferation	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	IBA	J:265628
Biological Process	GO:0007218	neuropeptide signaling pathway	IBA	J:265628
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:1903816	positive regulation of collecting lymphatic vessel constriction	ISO	J:155856
Biological Process	GO:0035815	positive regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0035810	positive regulation of urine volume	ISO	J:155856
Biological Process	GO:0006457	protein folding	ISO	J:164563
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	ISO	J:164563
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	IBA	J:265628
Biological Process	GO:0031667	response to nutrient levels	IDA	J:298695
Biological Process	GO:0070482	response to oxygen levels	IDA	J:298695