GO Annotations Graph

• Symbol: Npr1
• Name: natriuretic peptide receptor 1
• ID: MGI:97371

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0004383	guanylate cyclase activity	ISO	J:164563
Molecular Function	GO:0004383	guanylate cyclase activity	ISO	J:155856
Molecular Function	GO:0004383	guanylate cyclase activity	IBA	J:265628
Molecular Function	GO:0004383	guanylate cyclase activity	IDA	J:106135
Molecular Function	GO:0004383	guanylate cyclase activity	IDA	J:76460
Molecular Function	GO:0004383	guanylate cyclase activity	IMP	J:76460
Molecular Function	GO:0042562	hormone binding	ISO	J:164563
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0016941	natriuretic peptide receptor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:164563
Molecular Function	GO:0001653	peptide receptor activity	IBA	J:265628
Molecular Function	GO:0016849	phosphorus-oxygen lyase activity	IEA	J:72247
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:155856
Biological Process	GO:0006182	cGMP biosynthetic process	IMP	J:76460
Biological Process	GO:0006182	cGMP biosynthetic process	ISO	J:164563
Biological Process	GO:0006182	cGMP biosynthetic process	IBA	J:265628
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:0009190	cyclic nucleotide biosynthetic process	IEA	J:72247
Biological Process	GO:0042417	dopamine metabolic process	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	ISO	J:164563
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	ISO	J:155856
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	IBA	J:265628
Biological Process	GO:0008217	regulation of blood pressure	IDA	J:83298