GO Annotations Graph

• Symbol: Oprm1
• Name: opioid receptor, mu 1
• ID: MGI:97441

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004979	beta-endorphin receptor activity	ISO	J:164563
Molecular Function	GO:0004979	beta-endorphin receptor activity	IBA	J:265628
Molecular Function	GO:0031005	filamin binding	ISO	J:155856
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	IDA	J:322689
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	IDA	J:33119
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:155856
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:164563
Molecular Function	GO:0001965	G-protein alpha-subunit binding	IBA	J:265628
Molecular Function	GO:0031681	G-protein beta-subunit binding	ISO	J:155856
Molecular Function	GO:0031681	G-protein beta-subunit binding	IBA	J:265628
Molecular Function	GO:0038047	morphine receptor activity	ISO	J:155856
Molecular Function	GO:0038047	morphine receptor activity	IBA	J:265628
Molecular Function	GO:0042923	neuropeptide binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:200487
Molecular Function	GO:0005515	protein binding	IPI	J:248254
Molecular Function	GO:0005515	protein binding	IPI	J:177501
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:326512
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:326512
Cellular Component	GO:0098982	GABA-ergic synapse	EXP	J:326512
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:326512
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:33119
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9017925
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0097444	spine apparatus	ISO	J:155856
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	J:33119
Biological Process	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	J:33119
Biological Process	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048149	behavioral response to ethanol	ISO	J:164563
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	ISO	J:155856
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007626	locomotory behavior	IMP	J:62551
Biological Process	GO:0007626	locomotory behavior	IGI	J:81915
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0061358	negative regulation of Wnt protein secretion	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0032100	positive regulation of appetite	ISO	J:155856
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:180472
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:326512
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:326512
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:326512
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:326512
Biological Process	GO:0080135	regulation of cellular response to stress	ISO	J:164563
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	IMP	J:38597
Biological Process	GO:0019233	sensory perception of pain	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:60000