GO Annotations Graph

• Symbol: Pax8
• Name: paired box 8
• ID: MGI:97492

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISS	J:35102
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:54357
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:116251
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:117753
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:144755
Cellular Component	GO:0005634	nucleus	IDA	J:144755
Cellular Component	GO:0005667	transcription regulator complex	TAS	J:54357
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0009887	animal organ morphogenesis	TAS	J:54357
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	ISO	J:164563
Biological Process	GO:0007417	central nervous system development	IEP	J:72
Biological Process	GO:0006351	DNA-templated transcription	ISO	J:164563
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:47310
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:47310
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:163537
Biological Process	GO:0072073	kidney epithelium development	IEP	J:72
Biological Process	GO:0072164	mesonephric tubule development	IEP	J:72
Biological Process	GO:0001823	mesonephros development	IEP	J:72
Biological Process	GO:0001823	mesonephros development	IMP	J:80208
Biological Process	GO:0072221	metanephric distal convoluted tubule development	IMP	J:120229
Biological Process	GO:0072289	metanephric nephron tubule formation	IMP	J:120229
Biological Process	GO:0001656	metanephros development	IEP	J:72
Biological Process	GO:0001656	metanephros development	IGI	J:80208
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1900215	negative regulation of apoptotic process involved in metanephric collecting duct development	IMP	J:120229
Biological Process	GO:1900218	negative regulation of apoptotic process involved in metanephric nephron tubule development	IMP	J:120229
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:243393
Biological Process	GO:0072305	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	IMP	J:120229
Biological Process	GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP	J:120229
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:120229
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:120229
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:117753
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:31258
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:116251
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:115535
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:104408
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:80208
Biological Process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP	J:80208
Biological Process	GO:2000594	positive regulation of metanephric DCT cell differentiation	IMP	J:120229
Biological Process	GO:2000611	positive regulation of thyroid hormone generation	IMP	J:115535
Biological Process	GO:2000611	positive regulation of thyroid hormone generation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:41061
Biological Process	GO:0039003	pronephric field specification	IEP	J:80208
Biological Process	GO:0048793	pronephros development	IMP	J:80208
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:80208
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:54357
Biological Process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	IMP	J:120229
Biological Process	GO:2000612	regulation of thyroid-stimulating hormone secretion	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072050	S-shaped body morphogenesis	IEP	J:72
Biological Process	GO:0030878	thyroid gland development	IEP	J:72
Biological Process	GO:0030878	thyroid gland development	ISO	J:164563
Biological Process	GO:0030878	thyroid gland development	IMP	J:47310
Biological Process	GO:0030878	thyroid gland development	IGI	J:73626
Biological Process	GO:0030878	thyroid gland development	IMP	J:47310
Biological Process	GO:0001655	urogenital system development	IGI	J:80208
Biological Process	GO:0003281	ventricular septum development	IMP	J:243393