Furin GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Furin
furin, paired basic amino acid cleaving enzyme
MGI:97513

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:1904399	heparan sulfate binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0048406	nerve growth factor binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:95653
Molecular Function	GO:0008233	peptidase activity	ISO	J:90197
Molecular Function	GO:0042277	peptide binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:51716
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	EXP	J:81247
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004252	serine-type endopeptidase activity	TAS	Reactome:R-MMU-2484926
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0008236	serine-type peptidase activity	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005769	early endosome	TAS	J:79598
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1181148
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2484926
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0031985	Golgi cisterna	ISO	J:155856
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	TAS	J:79598
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Cellular Component	GO:0005802	trans-Golgi network	IBA	J:265628
Cellular Component	GO:0030140	trans-Golgi network transport vesicle	ISO	J:89488
Cellular Component	GO:0012510	trans-Golgi network transport vesicle membrane	TAS	J:79598
Biological Process	GO:0001825	blastocyst formation	IGI	J:227651
Biological Process	GO:0090472	dibasic protein processing	ISO	J:164563
Biological Process	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	ISO	J:164563
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	ISO	J:164563
Biological Process	GO:0032902	nerve growth factor production	ISO	J:164563
Biological Process	GO:0043043	peptide biosynthetic process	ISO	J:164563
Biological Process	GO:0016486	peptide hormone processing	ISO	J:164563
Biological Process	GO:0016486	peptide hormone processing	IBA	J:265628
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:1901394	positive regulation of transforming growth factor beta1 activation	ISO	J:164563
Biological Process	GO:0046598	positive regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0051604	protein maturation	ISO	J:164563
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0016485	protein processing	ISO	J:155856
Biological Process	GO:0016485	protein processing	IMP	J:203527
Biological Process	GO:0016485	protein processing	IMP	J:169483
Biological Process	GO:0016485	protein processing	ISO	J:95653
Biological Process	GO:0016485	protein processing	IDA	J:163721
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0032374	regulation of cholesterol transport	IMP	J:169483
Biological Process	GO:0052548	regulation of endopeptidase activity	ISO	J:164563
Biological Process	GO:0042176	regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0009966	regulation of signal transduction	IDA	J:127541
Biological Process	GO:0032940	secretion by cell	ISO	J:164563
Biological Process	GO:0006465	signal peptide processing	ISO	J:164563
Biological Process	GO:0031638	zymogen activation	ISO	J:164563
Biological Process	GO:0097341	zymogen inhibition	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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