GO Annotations Graph

• Symbol: Pcsk4
• Name: proprotein convertase subtilisin/kexin type 4
• ID: MGI:97514

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0002080	acrosomal membrane	IDA	J:107011
Cellular Component	GO:0001669	acrosomal vesicle	IDA	J:233572
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005802	trans-Golgi network	IBA	J:265628
Biological Process	GO:0007340	acrosome reaction	IMP	J:107011
Biological Process	GO:0007339	binding of sperm to zona pellucida	IMP	J:107011
Biological Process	GO:0009566	fertilization	IMP	J:41503
Biological Process	GO:0009566	fertilization	IDA	J:233572
Biological Process	GO:0009566	fertilization	IMP	J:107011
Biological Process	GO:0016486	peptide hormone processing	IBA	J:265628
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0022414	reproductive process	IMP	J:41503
Biological Process	GO:0048240	sperm capacitation	IDA	J:233572
Biological Process	GO:0048240	sperm capacitation	IMP	J:233577
Biological Process	GO:0048240	sperm capacitation	IMP	J:107011