GO Annotations Graph

• Symbol: Pdgfb
• Name: platelet derived growth factor, B polypeptide
• ID: MGI:97528

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	ISO	J:73065
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0016176	superoxide-generating NADPH oxidase activator activity	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:1990265	platelet-derived growth factor complex	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:105981
Biological Process	GO:0030036	actin cytoskeleton organization	IDA	J:78781
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0001568	blood vessel development	IEP	J:20328
Biological Process	GO:0048514	blood vessel morphogenesis	IGI	J:100933
Biological Process	GO:0048514	blood vessel morphogenesis	IDA	J:100933
Biological Process	GO:0060445	branching involved in salivary gland morphogenesis	IMP	J:140258
Biological Process	GO:0060947	cardiac vascular smooth muscle cell differentiation	TAS	J:169941
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0016477	cell migration	IGI	J:109530
Biological Process	GO:0030031	cell projection assembly	IDA	J:78781
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0071506	cellular response to mycophenolic acid	ISO	J:155856
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IDA	J:314648
Biological Process	GO:0001892	embryonic placenta development	IMP	J:89186
Biological Process	GO:0001935	endothelial cell proliferation	IGI	J:109530
Biological Process	GO:0001935	endothelial cell proliferation	IGI	J:109530
Biological Process	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IMP	J:140258
Biological Process	GO:0042462	eye photoreceptor cell development	IMP	J:215977
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IDA	J:140258
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IDA	J:140258
Biological Process	GO:0010761	fibroblast migration	IDA	J:92200
Biological Process	GO:0010761	fibroblast migration	IGI	J:105981
Biological Process	GO:0021782	glial cell development	IMP	J:215977
Biological Process	GO:0007507	heart development	IMP	J:89186
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0072264	metanephric glomerular endothelium development	IEP	J:50064
Biological Process	GO:0072255	metanephric glomerular mesangial cell development	IMP	J:89186
Biological Process	GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	IMP	J:50064
Biological Process	GO:0002548	monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:1902894	negative regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0010544	negative regulation of platelet activation	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:1905064	negative regulation of vascular associated smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	IGI	J:109530
Biological Process	GO:0016322	neuron remodeling	IMP	J:215977
Biological Process	GO:0038001	paracrine signaling	IMP	J:89186
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	NAS	J:320129
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0090280	positive regulation of calcium ion import	ISO	J:164563
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:164563
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	TAS	J:139512
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IGI	J:109530
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	IDA	J:140258
Biological Process	GO:0010763	positive regulation of fibroblast migration	IGI	J:105981
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:314648
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:314648
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0003104	positive regulation of glomerular filtration	IMP	J:89186
Biological Process	GO:0072126	positive regulation of glomerular mesangial cell proliferation	ISO	J:164563
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:1904899	positive regulation of hepatic stellate cell proliferation	ISO	J:155856
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:2000591	positive regulation of metanephric mesenchymal cell migration	ISO	J:164563
Biological Process	GO:2000591	positive regulation of metanephric mesenchymal cell migration	ISO	J:155856
Biological Process	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0045977	positive regulation of mitotic cell cycle, embryonic	IGI	J:140959
Biological Process	GO:0045977	positive regulation of mitotic cell cycle, embryonic	IGI	J:140959
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:164563
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	IBA	J:265628
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IMP	J:20328
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IDA	J:314648
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IMP	J:20328
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1905176	positive regulation of vascular associated smooth muscle cell dedifferentiation	ISO	J:164563
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	IGI	J:109530
Biological Process	GO:0045907	positive regulation of vasoconstriction	TAS	J:169941
Biological Process	GO:0070528	protein kinase C signaling	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IDA	J:77668
Biological Process	GO:0009611	response to wounding	ISO	J:164563
Biological Process	GO:0060041	retina development in camera-type eye	IMP	J:215977
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:215977
Biological Process	GO:0006929	substrate-dependent cell migration	IDA	J:92200
Biological Process	GO:0007416	synapse assembly	IMP	J:215977
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	IGI	J:109530
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	IGI	J:109530
Biological Process	GO:0042310	vasoconstriction	TAS	J:169941