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GO Annotations Graph
Symbol
Name
ID
Pdgfb
platelet derived growth factor, B polypeptide
MGI:97528

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0042056chemoattractant activityISOJ:164563
Molecular FunctionGO:0005518collagen bindingISOJ:73065
Molecular FunctionGO:0008083growth factor activityISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0048407platelet-derived growth factor bindingISOJ:164563
Molecular FunctionGO:0005161platelet-derived growth factor receptor bindingISOJ:164563
Molecular FunctionGO:0005161platelet-derived growth factor receptor bindingIBAJ:265628
Molecular FunctionGO:0046982protein heterodimerization activityISOJ:164563
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0005102signaling receptor bindingISOJ:155856
Molecular FunctionGO:0016176superoxide-generating NADPH oxidase activator activityISOJ:164563
Cellular ComponentGO:0016323basolateral plasma membraneISOJ:155856
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0030425dendriteISOJ:155856
Cellular ComponentGO:0005576extracellular regionIEAJ:60000
Cellular ComponentGO:0005615extracellular spaceISOJ:155856
Cellular ComponentGO:0005615extracellular spaceIBAJ:265628
Cellular ComponentGO:0016020membraneIEAJ:72247
Cellular ComponentGO:0043025neuronal cell bodyISOJ:155856
Cellular ComponentGO:1990265platelet-derived growth factor complexISOJ:164563
Biological ProcessGO:0030036actin cytoskeleton organizationIGIJ:105981
Biological ProcessGO:0030036actin cytoskeleton organizationIDAJ:78781
Biological ProcessGO:0032147activation of protein kinase activityISOJ:164563
Biological ProcessGO:0032148activation of protein kinase B activityISOJ:164563
Biological ProcessGO:0001568blood vessel developmentIEPJ:20328
Biological ProcessGO:0048514blood vessel morphogenesisIGIJ:100933
Biological ProcessGO:0048514blood vessel morphogenesisIDAJ:100933
Biological ProcessGO:0060445branching involved in salivary gland morphogenesisIMPJ:140258
Biological ProcessGO:0060947cardiac vascular smooth muscle cell differentiationTASJ:169941
Biological ProcessGO:0060326cell chemotaxisISOJ:164563
Biological ProcessGO:0016477cell migrationIGIJ:109530
Biological ProcessGO:0030031cell projection assemblyIDAJ:78781
Biological ProcessGO:0071363cellular response to growth factor stimulusISOJ:164563
Biological ProcessGO:0071506cellular response to mycophenolic acidISOJ:155856
Biological ProcessGO:0036120cellular response to platelet-derived growth factor stimulusIDAJ:314648
Biological ProcessGO:0001892embryonic placenta developmentIMPJ:89186
Biological ProcessGO:0001935endothelial cell proliferationIGIJ:109530
Biological ProcessGO:0001935endothelial cell proliferationIGIJ:109530
Biological ProcessGO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIMPJ:140258
Biological ProcessGO:0042462eye photoreceptor cell developmentIMPJ:215977
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayIDAJ:140258
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayIDAJ:140258
Biological ProcessGO:0010761fibroblast migrationIDAJ:92200
Biological ProcessGO:0010761fibroblast migrationIGIJ:105981
Biological ProcessGO:0021782glial cell developmentIMPJ:215977
Biological ProcessGO:0007507heart developmentIMPJ:89186
Biological ProcessGO:0035655interleukin-18-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0072264metanephric glomerular endothelium developmentIEPJ:50064
Biological ProcessGO:0072255metanephric glomerular mesangial cell developmentIMPJ:89186
Biological ProcessGO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros developmentIMPJ:50064
Biological ProcessGO:0002548monocyte chemotaxisISOJ:164563
Biological ProcessGO:0007275multicellular organism developmentIEAJ:60000
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionISOJ:164563
Biological ProcessGO:0010629negative regulation of gene expressionISOJ:164563
Biological ProcessGO:1902894negative regulation of miRNA transcriptionISOJ:164563
Biological ProcessGO:0010512negative regulation of phosphatidylinositol biosynthetic processISOJ:164563
Biological ProcessGO:0010544negative regulation of platelet activationISOJ:164563
Biological ProcessGO:0032091negative regulation of protein bindingISOJ:164563
Biological ProcessGO:1905064negative regulation of vascular associated smooth muscle cell differentiationISOJ:164563
Biological ProcessGO:1904753negative regulation of vascular associated smooth muscle cell migrationIGIJ:109530
Biological ProcessGO:0016322neuron remodelingIMPJ:215977
Biological ProcessGO:0038001paracrine signalingIMPJ:89186
Biological ProcessGO:0018105peptidyl-serine phosphorylationISOJ:164563
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationISOJ:164563
Biological ProcessGO:0014065phosphatidylinositol 3-kinase signalingIGIJ:105981
Biological ProcessGO:0014065phosphatidylinositol 3-kinase signalingIGIJ:105981
Biological ProcessGO:0048008platelet-derived growth factor receptor signaling pathwayISOJ:164563
Biological ProcessGO:0048008platelet-derived growth factor receptor signaling pathwayISOJ:155856
Biological ProcessGO:0048008platelet-derived growth factor receptor signaling pathwayNASJ:320129
Biological ProcessGO:0048008platelet-derived growth factor receptor signaling pathwayIBAJ:265628
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationISOJ:164563
Biological ProcessGO:0090280positive regulation of calcium ion importISOJ:164563
Biological ProcessGO:0051781positive regulation of cell divisionIEAJ:60000
Biological ProcessGO:0030335positive regulation of cell migrationISOJ:164563
Biological ProcessGO:0030335positive regulation of cell migrationIBAJ:265628
Biological ProcessGO:0008284positive regulation of cell population proliferationISOJ:164563
Biological ProcessGO:0008284positive regulation of cell population proliferationIBAJ:265628
Biological ProcessGO:0010811positive regulation of cell-substrate adhesionISOJ:164563
Biological ProcessGO:0050921positive regulation of chemotaxisISOJ:164563
Biological ProcessGO:0032967positive regulation of collagen biosynthetic processISOJ:155856
Biological ProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityISOJ:164563
Biological ProcessGO:2000573positive regulation of DNA biosynthetic processISOJ:164563
Biological ProcessGO:0045740positive regulation of DNA replicationISOJ:155856
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionISOJ:164563
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionISOJ:155856
Biological ProcessGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayTASJ:139512
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationISOJ:164563
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationIGIJ:109530
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:164563
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIBAJ:265628
Biological ProcessGO:0045743positive regulation of fibroblast growth factor receptor signaling pathwayIDAJ:140258
Biological ProcessGO:0010763positive regulation of fibroblast migrationIGIJ:105981
Biological ProcessGO:0048146positive regulation of fibroblast proliferationISOJ:164563
Biological ProcessGO:0010628positive regulation of gene expressionIDAJ:314648
Biological ProcessGO:0010628positive regulation of gene expressionIDAJ:314648
Biological ProcessGO:0010628positive regulation of gene expressionISOJ:164563
Biological ProcessGO:0003104positive regulation of glomerular filtrationIMPJ:89186
Biological ProcessGO:0072126positive regulation of glomerular mesangial cell proliferationISOJ:164563
Biological ProcessGO:2000491positive regulation of hepatic stellate cell activationISOJ:155856
Biological ProcessGO:1904899positive regulation of hepatic stellate cell proliferationISOJ:155856
Biological ProcessGO:1900127positive regulation of hyaluronan biosynthetic processISOJ:164563
Biological ProcessGO:0043406positive regulation of MAP kinase activityISOJ:164563
Biological ProcessGO:0043406positive regulation of MAP kinase activityISOJ:155856
Biological ProcessGO:0043406positive regulation of MAP kinase activityIBAJ:265628
Biological ProcessGO:0043410positive regulation of MAPK cascadeISOJ:164563
Biological ProcessGO:2000591positive regulation of metanephric mesenchymal cell migrationISOJ:164563
Biological ProcessGO:2000591positive regulation of metanephric mesenchymal cell migrationISOJ:155856
Biological ProcessGO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayISOJ:164563
Biological ProcessGO:1902895positive regulation of miRNA transcriptionISOJ:164563
Biological ProcessGO:0045977positive regulation of mitotic cell cycle, embryonicIGIJ:140959
Biological ProcessGO:0045977positive regulation of mitotic cell cycle, embryonicIGIJ:140959
Biological ProcessGO:0045840positive regulation of mitotic nuclear divisionISOJ:164563
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationISOJ:164563
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activityISOJ:164563
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingISOJ:164563
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIBAJ:265628
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIGIJ:105981
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIGIJ:105981
Biological ProcessGO:0031954positive regulation of protein autophosphorylationISOJ:164563
Biological ProcessGO:0031954positive regulation of protein autophosphorylationIBAJ:265628
Biological ProcessGO:0061098positive regulation of protein tyrosine kinase activityISOJ:164563
Biological ProcessGO:2000379positive regulation of reactive oxygen species metabolic processISOJ:164563
Biological ProcessGO:0014911positive regulation of smooth muscle cell migrationISOJ:164563
Biological ProcessGO:0014911positive regulation of smooth muscle cell migrationISOJ:155856
Biological ProcessGO:0014911positive regulation of smooth muscle cell migrationIMPJ:20328
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationIDAJ:314648
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:164563
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationIMPJ:20328
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:155856
Biological ProcessGO:1905176positive regulation of vascular associated smooth muscle cell dedifferentiationISOJ:164563
Biological ProcessGO:1904754positive regulation of vascular associated smooth muscle cell migrationISOJ:164563
Biological ProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationISOJ:164563
Biological ProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationIGIJ:109530
Biological ProcessGO:0045907positive regulation of vasoconstrictionTASJ:169941
Biological ProcessGO:0070528protein kinase C signalingISOJ:164563
Biological ProcessGO:0006468protein phosphorylationISOJ:164563
Biological ProcessGO:0072593reactive oxygen species metabolic processISOJ:164563
Biological ProcessGO:0050730regulation of peptidyl-tyrosine phosphorylationIDAJ:77668
Biological ProcessGO:0009611response to woundingISOJ:164563
Biological ProcessGO:0060041retina development in camera-type eyeIMPJ:215977
Biological ProcessGO:0061298retina vasculature development in camera-type eyeIMPJ:215977
Biological ProcessGO:0006929substrate-dependent cell migrationIDAJ:92200
Biological ProcessGO:0007416synapse assemblyIMPJ:215977
Biological ProcessGO:1904738vascular associated smooth muscle cell migrationIGIJ:109530
Biological ProcessGO:1990874vascular associated smooth muscle cell proliferationIGIJ:109530
Biological ProcessGO:0042310vasoconstrictionTASJ:169941

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory