GO Annotations Graph

• Symbol: Pdgfra
• Name: platelet derived growth factor receptor, alpha polypeptide
• ID: MGI:97530

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0062063	BBSome binding	IDA	J:194096
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	IDA	J:177243
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	ISO	J:164563
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	ISO	J:155856
Molecular Function	GO:0005018	platelet-derived growth factor alpha-receptor activity	IBA	J:265628
Molecular Function	GO:0048407	platelet-derived growth factor binding	IDA	J:177243
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:164563
Molecular Function	GO:0048407	platelet-derived growth factor binding	TAS	J:169941
Molecular Function	GO:0048407	platelet-derived growth factor binding	IBA	J:265628
Molecular Function	GO:0048407	platelet-derived growth factor binding	IDA	J:93392
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:207686
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0038085	vascular endothelial growth factor binding	ISO	J:164563
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IDA	J:190263
Cellular Component	GO:0005929	cilium	IDA	J:281256
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:180687
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:185712
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:281256
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005902	microvillus	IDA	J:194289
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:170416
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:207686
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0030325	adrenal gland development	IGI	J:142042
Biological Process	GO:0009653	anatomical structure morphogenesis	IMP	J:95139
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:62052
Biological Process	GO:0055003	cardiac myofibril assembly	IGI	J:67735
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	IMP	J:177243
Biological Process	GO:0016477	cell migration	IMP	J:177243
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:207686
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:41814
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IBA	J:265628
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	IMP	J:63212
Biological Process	GO:0008210	estrogen metabolic process	IGI	J:142042
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:95139
Biological Process	GO:0060325	face morphogenesis	IMP	J:117491
Biological Process	GO:0008585	female gonad development	IGI	J:142042
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:202604
Biological Process	GO:0001701	in utero embryonic development	IMP	J:54912
Biological Process	GO:0001701	in utero embryonic development	IMP	J:117491
Biological Process	GO:0033327	Leydig cell differentiation	IMP	J:142042
Biological Process	GO:0030324	lung development	IMP	J:108040
Biological Process	GO:0060437	lung growth	ISO	J:155856
Biological Process	GO:0001553	luteinization	IMP	J:142042
Biological Process	GO:0001553	luteinization	IGI	J:142042
Biological Process	GO:0030539	male genitalia development	IMP	J:82564
Biological Process	GO:0072277	metanephric glomerular capillary formation	IGI	J:67735
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0010544	negative regulation of platelet activation	ISO	J:164563
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:95139
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:177243
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:117491
Biological Process	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	IDA	J:177243
Biological Process	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	ISO	J:164563
Biological Process	GO:0061047	positive regulation of branching involved in lung morphogenesis	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0010863	positive regulation of phospholipase C activity	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:177243
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:164563
Biological Process	GO:2000739	regulation of mesenchymal stem cell differentiation	ISO	J:164563
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IGI	J:67735
Biological Process	GO:0060021	roof of mouth development	IMP	J:117491
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IDA	J:155850
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:117491
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0050872	white fat cell differentiation	IMP	J:238410
Biological Process	GO:0050872	white fat cell differentiation	IMP	J:238410
Biological Process	GO:0042060	wound healing	IMP	J:177243