GO Annotations Graph

• Symbol: Pdgfrb
• Name: platelet derived growth factor receptor, beta polypeptide
• ID: MGI:97531

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IMP	J:83953
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0005019	platelet-derived growth factor beta-receptor activity	ISO	J:164563
Molecular Function	GO:0005019	platelet-derived growth factor beta-receptor activity	IBA	J:265628
Molecular Function	GO:0048407	platelet-derived growth factor binding	TAS	J:169941
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:164563
Molecular Function	GO:0048407	platelet-derived growth factor binding	IBA	J:265628
Molecular Function	GO:0005017	platelet-derived growth factor receptor activity	ISO	J:155856
Molecular Function	GO:0005017	platelet-derived growth factor receptor activity	IDA	J:227201
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:172000
Molecular Function	GO:0005515	protein binding	IPI	J:248243
Molecular Function	GO:0005515	protein binding	IPI	J:201319
Molecular Function	GO:0005515	protein binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:200398
Molecular Function	GO:0005515	protein binding	IPI	J:172913
Molecular Function	GO:0005515	protein binding	IPI	J:200358
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:105981
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0038085	vascular endothelial growth factor binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:202604
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:202604
Cellular Component	GO:0005737	cytoplasm	IDA	J:180687
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0001726	ruffle	IDA	J:227201
Biological Process	GO:0030325	adrenal gland development	IGI	J:142042
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:153626
Biological Process	GO:0001568	blood vessel development	IEP	J:20328
Biological Process	GO:0055003	cardiac myofibril assembly	IGI	J:67735
Biological Process	GO:0060947	cardiac vascular smooth muscle cell differentiation	TAS	J:169941
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	IBA	J:265628
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0060981	cell migration involved in coronary angiogenesis	IMP	J:86542
Biological Process	GO:0035441	cell migration involved in vasculogenesis	IMP	J:86542
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:202378
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0048568	embryonic organ development	IEP	J:20328
Biological Process	GO:0006024	glycosaminoglycan biosynthetic process	ISO	J:155856
Biological Process	GO:0001701	in utero embryonic development	IMP	J:117491
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0001822	kidney development	IMP	J:117491
Biological Process	GO:0060437	lung growth	ISO	J:155856
Biological Process	GO:0072277	metanephric glomerular capillary formation	IGI	J:67735
Biological Process	GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	IMP	J:50064
Biological Process	GO:0072223	metanephric glomerular mesangium development	IEP	J:50064
Biological Process	GO:0035789	metanephric mesenchymal cell migration	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0006807	nitrogen compound metabolic process	IMP	J:117491
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:86542
Biological Process	GO:0046488	phosphatidylinositol metabolic process	ISO	J:164563
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:117491
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IPI	J:227201
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0090280	positive regulation of calcium ion import	IMP	J:175150
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	IDA	J:175150
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	IMP	J:175150
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:86542
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:172977
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:172977
Biological Process	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IMP	J:175150
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IDA	J:172977
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:172977
Biological Process	GO:0010863	positive regulation of phospholipase C activity	ISO	J:164563
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	IMP	J:175150
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IGI	J:153626
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IMP	J:20328
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	IBA	J:265628
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IMP	J:20328
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:86542
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IGI	J:153626
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IMP	J:77668
Biological Process	GO:0106096	response to ceramide	IMP	J:202378
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:86542
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IGI	J:67735
Biological Process	GO:0097178	ruffle assembly	IDA	J:227201
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IDA	J:77668
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:117491
Biological Process	GO:0071670	smooth muscle cell chemotaxis	IGI	J:153626
Biological Process	GO:0048745	smooth muscle tissue development	IMP	J:117491
Biological Process	GO:0001894	tissue homeostasis	IMP	J:117491
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628