GO Annotations Graph

• Symbol: Pecam1
• Name: platelet/endothelial cell adhesion molecule 1
• ID: MGI:97537

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:68671
Molecular Function	GO:0005515	protein binding	IPI	J:68671
Molecular Function	GO:0005515	protein binding	IPI	J:58498
Molecular Function	GO:0005515	protein binding	IPI	J:186896
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0071944	cell periphery	IDA	J:171374
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0044291	cell-cell contact zone	IDA	J:186896
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:186896
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:162997
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:147119
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:206413
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:132871
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:174203
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:110719
Cellular Component	GO:0045121	membrane raft	IDA	J:84696
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:102190
Cellular Component	GO:0005886	plasma membrane	IDA	J:84143
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Cellular Component	GO:0030485	smooth muscle contractile fiber	IDA	J:136004
Cellular Component	GO:0030485	smooth muscle contractile fiber	IDA	J:136004
Biological Process	GO:0001525	angiogenesis	IMP	J:125014
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IDA	J:186896
Biological Process	GO:0007166	cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:164563
Biological Process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	ISO	J:164563
Biological Process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	IBA	J:265628
Biological Process	GO:0050904	diapedesis	ISO	J:164563
Biological Process	GO:0043542	endothelial cell migration	IMP	J:125014
Biological Process	GO:0001886	endothelial cell morphogenesis	IMP	J:125014
Biological Process	GO:0090673	endothelial cell-matrix adhesion	IMP	J:125014
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0035696	monocyte extravasation	ISO	J:164563
Biological Process	GO:0030837	negative regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:0034260	negative regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0072672	neutrophil extravasation	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0002693	positive regulation of cellular extravasation	ISO	J:155856
Biological Process	GO:0002687	positive regulation of leukocyte migration	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0150107	positive regulation of protein localization to cell-cell junction	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:68671
Biological Process	GO:0030334	regulation of cell migration	IMP	J:84696
Biological Process	GO:0007266	Rho protein signal transduction	IMP	J:84696
Biological Process	GO:0042060	wound healing	IMP	J:84696