GO Annotations Graph

• Symbol: Pfn1
• Name: profilin 1
• ID: MGI:97549

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0003785	actin monomer binding	ISO	J:164563
Molecular Function	GO:0000774	adenyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:155856
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:201457
Molecular Function	GO:0005515	protein binding	IPI	J:95526
Molecular Function	GO:0005515	protein binding	IPI	J:74533
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	IPI	J:148081
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:77643
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-482767
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5665656
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-482767
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:231072
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231072
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:95526
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	IEA	J:72247
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	IDA	J:231072
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	IDA	J:231072
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	IDA	J:231072
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	IMP	J:231072
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	IDA	J:231072
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:231072
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:231072
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:231072
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:231072
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:231072
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0030837	negative regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IGI	J:53259
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	IBA	J:265628
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	ISO	J:164563
Biological Process	GO:0051054	positive regulation of DNA metabolic process	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:1900029	positive regulation of ruffle assembly	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0050434	positive regulation of viral transcription	ISO	J:155856
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0030833	regulation of actin filament polymerization	IBA	J:265628
Biological Process	GO:0008064	regulation of actin polymerization or depolymerization	TAS	J:77643
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:95526
Biological Process	GO:0042989	sequestering of actin monomers	TAS	J:77643
Biological Process	GO:0060074	synapse maturation	IDA	J:231072
Biological Process	GO:0060074	synapse maturation	IMP	J:231072
Biological Process	GO:0060074	synapse maturation	IDA	J:231072
Biological Process	GO:0060074	synapse maturation	IDA	J:231072