GO Annotations Graph

• Symbol: Prf1
• Name: perforin 1 (pore forming protein)
• ID: MGI:97551

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IDA	J:326899
Molecular Function	GO:0005509	calcium ion binding	IDA	J:175325
Molecular Function	GO:0005509	calcium ion binding	IDA	J:327044
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0022829	wide pore channel activity	ISO	J:164563
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:326899
Molecular Function	GO:0022829	wide pore channel activity	IBA	J:265628
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:326897
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:326897
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:327044
Molecular Function	GO:0022829	wide pore channel activity	IDA	J:175325
Cellular Component	GO:0044194	cytolytic granule	IDA	J:17986
Cellular Component	GO:0044194	cytolytic granule	ISO	J:164563
Cellular Component	GO:0044194	cytolytic granule	IDA	J:157393
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:76353
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0001772	immunological synapse	IDA	J:17986
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:326899
Cellular Component	GO:0016020	membrane	IDA	J:175325
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:326897
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0007623	circadian rhythm	ISO	J:155856
Biological Process	GO:0019835	cytolysis	IEA	J:72247
Biological Process	GO:0019835	cytolysis	IEA	J:60000
Biological Process	GO:0002357	defense response to tumor cell	IMP	J:17986
Biological Process	GO:0051607	defense response to virus	IMP	J:17986
Biological Process	GO:0051607	defense response to virus	IBA	J:265628
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	IDA	J:326897
Biological Process	GO:0002418	immune response to tumor cell	IMP	J:17986
Biological Process	GO:0001771	immunological synapse formation	ISO	J:164563
Biological Process	GO:0001771	immunological synapse formation	IBA	J:265628
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	IDA	J:175325
Biological Process	GO:0051260	protein homooligomerization	IDA	J:326899
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0017038	protein import	ISO	J:164563
Biological Process	GO:0017038	protein import	IDA	J:175325
Biological Process	GO:0009306	protein secretion	IDA	J:326897
Biological Process	GO:0071806	protein transmembrane transport	ISO	J:164563
Biological Process	GO:0071806	protein transmembrane transport	IDA	J:175325
Biological Process	GO:0001913	T cell mediated cytotoxicity	IBA	J:265628
Biological Process	GO:0001913	T cell mediated cytotoxicity	IDA	J:175325
Biological Process	GO:0001913	T cell mediated cytotoxicity	IDA	J:327044
Biological Process	GO:0001913	T cell mediated cytotoxicity	IDA	J:96611