GO Annotations Graph

• Symbol: Phb1
• Name: prohibitin 1
• ID: MGI:97572

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001850	complement component C3a binding	ISO	J:164563
Molecular Function	GO:0001851	complement component C3b binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:191189
Molecular Function	GO:0005515	protein binding	IPI	J:215238
Molecular Function	GO:0005515	protein binding	IPI	J:273588
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0031871	proteinase activated receptor binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:140901
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:219621
Cellular Component	GO:0005737	cytoplasm	IDA	J:289457
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0098891	extrinsic component of presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:273588
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0035632	mitochondrial prohibitin complex	ISO	J:164563
Cellular Component	GO:0035632	mitochondrial prohibitin complex	IPI	J:273588
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:289457
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:129870
Cellular Component	GO:0005739	mitochondrion	IDA	J:131696
Cellular Component	GO:0005739	mitochondrion	IDA	J:242350
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:273588
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:140901
Cellular Component	GO:0005886	plasma membrane	IDA	J:289457
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0007202	activation of phospholipase C activity	IDA	J:191189
Biological Process	GO:1990051	activation of protein kinase C activity	IDA	J:191189
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0042113	B cell activation	IDA	J:191189
Biological Process	GO:0023035	CD40 signaling pathway	IDA	J:191189
Biological Process	GO:0071354	cellular response to interleukin-6	ISO	J:164563
Biological Process	GO:0071897	DNA biosynthetic process	IMP	J:140901
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	NAS	J:136807
Biological Process	GO:0007005	mitochondrion organization	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	IBA	J:265628
Biological Process	GO:0044830	modulation by host of viral RNA genome replication	IDA	J:289457
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:140901
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0045917	positive regulation of complement activation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IDA	J:191189
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	J:191189
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0050847	progesterone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0039529	RIG-I signaling pathway	ISO	J:164563
Biological Process	GO:0072538	T-helper 17 type immune response	ISO	J:164563
Biological Process	GO:0046718	viral entry into host cell	IDA	J:289457