GO Annotations Graph

• Symbol: Pkm
• Name: pyruvate kinase, muscle
• ID: MGI:97591

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003729	mRNA binding	IDA	J:277769
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030955	potassium ion binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:131445
Molecular Function	GO:0005515	protein binding	IPI	J:201315
Molecular Function	GO:0005515	protein binding	IPI	J:220572
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004743	pyruvate kinase activity	ISO	J:164563
Molecular Function	GO:0004743	pyruvate kinase activity	ISO	J:155856
Molecular Function	GO:0004743	pyruvate kinase activity	ISO	J:164563
Molecular Function	GO:0004743	pyruvate kinase activity	IBA	J:265628
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6558
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6558
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0070324	thyroid hormone binding	ISO	J:155856
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005929	cilium	IDA	J:111771
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:219975
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:1902912	pyruvate kinase complex	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	IDA	J:277769
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0006754	ATP biosynthetic process	ISO	J:155856
Biological Process	GO:0061621	canonical glycolysis	IDA	J:243273
Biological Process	GO:0032869	cellular response to insulin stimulus	IBA	J:265628
Biological Process	GO:0006006	glucose metabolic process	ISO	J:155856
Biological Process	GO:0006096	glycolytic process	ISO	J:164563
Biological Process	GO:0006096	glycolytic process	ISO	J:155856
Biological Process	GO:0006096	glycolytic process	IBA	J:265628
Biological Process	GO:0006096	glycolytic process	IDA	J:6558
Biological Process	GO:0006096	glycolytic process	IDA	J:6558
Biological Process	GO:0006096	glycolytic process	IDA	J:6625
Biological Process	GO:0001889	liver development	ISO	J:155856
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2000767	positive regulation of cytoplasmic translation	IDA	J:277769
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	ISO	J:164563
Biological Process	GO:0051289	protein homotetramerization	ISO	J:155856
Biological Process	GO:0051262	protein tetramerization	ISO	J:155856
Biological Process	GO:0042866	pyruvate biosynthetic process	ISO	J:155856
Biological Process	GO:0006090	pyruvate metabolic process	ISO	J:155856
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0043403	skeletal muscle tissue regeneration	ISO	J:155856