GO Annotations Graph

• Symbol: Prkacb
• Name: protein kinase, cAMP dependent, catalytic, beta
• ID: MGI:97594

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IEA	J:72245
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IDA	J:44175
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	ISO	J:155856
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IDA	J:44175
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:44175
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-163422
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-5610710
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-NUL-5610740
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	ISO	J:155856
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	TAS	J:44175
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0097546	ciliary base	IDA	J:181006
Cellular Component	GO:0097546	ciliary base	IDA	J:181006
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-163422
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5610710
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9010662
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610740
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	J:44175
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	ISO	J:155856
Biological Process	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI	J:181006
Biological Process	GO:0001843	neural tube closure	IGI	J:181006
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010737	protein kinase A signaling	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:44175
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0070613	regulation of protein processing	IGI	J:181006