GO Annotations Graph

• Symbol: Prkca
• Name: protein kinase C, alpha
• ID: MGI:97595

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IMP	J:240312
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	ISO	J:164563
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	ISO	J:155856
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IDA	J:74087
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IDA	J:25262
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0035403	histone H3T6 kinase activity	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IPI	J:175183
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0008289	lipid binding	EXP	J:326236
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200511
Molecular Function	GO:0005515	protein binding	IPI	J:280563
Molecular Function	GO:0005515	protein binding	IPI	J:82431
Molecular Function	GO:0005515	protein binding	IPI	J:173008
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:164563
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:155856
Molecular Function	GO:0004697	protein kinase C activity	IDA	J:219061
Molecular Function	GO:0004697	protein kinase C activity	IMP	J:240312
Molecular Function	GO:0004697	protein kinase C activity	IDA	J:82431
Molecular Function	GO:0004697	protein kinase C activity	IDA	J:85495
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:88510
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0035866	alphav-beta3 integrin-PKCalpha complex	IDA	J:175183
Cellular Component	GO:0045177	apical part of cell	IDA	J:199301
Cellular Component	GO:0030424	axon	IDA	J:137216
Cellular Component	GO:0044305	calyx of Held	IDA	J:174964
Cellular Component	GO:0044305	calyx of Held	IDA	J:174964
Cellular Component	GO:0044305	calyx of Held	IMP	J:174964
Cellular Component	GO:0044305	calyx of Held	IDA	J:174964
Cellular Component	GO:0036064	ciliary basal body	ISO	J:164563
Cellular Component	GO:0120199	cone photoreceptor outer segment	IDA	J:61812
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:85082
Cellular Component	GO:0005737	cytoplasm	IDA	J:87315
Cellular Component	GO:0005737	cytoplasm	IDA	J:63657
Cellular Component	GO:0005737	cytoplasm	IDA	J:63657
Cellular Component	GO:0005737	cytoplasm	IDA	J:199456
Cellular Component	GO:0005737	cytoplasm	IDA	J:85668
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9010658
Cellular Component	GO:0030425	dendrite	IDA	J:77234
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0014704	intercalated disc	IDA	J:240063
Cellular Component	GO:0016020	membrane	IDA	J:149031
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:85668
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:77234
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0005634	nucleus	IDA	J:87315
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0005634	nucleus	IDA	J:94623
Cellular Component	GO:1990917	ooplasm	IDA	J:94623
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:63657
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:174964
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:174964
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:240063
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IGI	J:131178
Biological Process	GO:0071322	cellular response to carbohydrate stimulus	IDA	J:121666
Biological Process	GO:0021955	central nervous system neuron axonogenesis	ISO	J:155856
Biological Process	GO:0002062	chondrocyte differentiation	IDA	J:125386
Biological Process	GO:0002159	desmosome assembly	ISO	J:164563
Biological Process	GO:0050930	induction of positive chemotaxis	IMP	J:85082
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:88510
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IMP	J:85082
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0046716	muscle cell cellular homeostasis	IMP	J:88510
Biological Process	GO:0010360	negative regulation of anion channel activity	IMP	J:240312
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:131178
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	ISO	J:164563
Biological Process	GO:0046325	negative regulation of glucose import	IMP	J:85923
Biological Process	GO:0045822	negative regulation of heart contraction	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IMP	J:85923
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:85923
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:85923
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:88510
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IGI	J:204152
Biological Process	GO:0017148	negative regulation of translation	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:85082
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	IDA	J:111556
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:175183
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:2000707	positive regulation of dense core granule biogenesis	IMP	J:145973
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0045921	positive regulation of exocytosis	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:85082
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045651	positive regulation of macrophage differentiation	IMP	J:180500
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:88510
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:155856
Biological Process	GO:0043687	post-translational protein modification	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:174964
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:174964
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:280563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:82431
Biological Process	GO:0006468	protein phosphorylation	IMP	J:88510
Biological Process	GO:0006468	protein phosphorylation	IDA	J:25262
Biological Process	GO:0006468	protein phosphorylation	IMP	J:88510
Biological Process	GO:0006468	protein phosphorylation	IMP	J:88510
Biological Process	GO:0006468	protein phosphorylation	IGI	J:204152
Biological Process	GO:0006937	regulation of muscle contraction	IMP	J:88510
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IMP	J:77668
Biological Process	GO:0090330	regulation of platelet aggregation	IMP	J:145973
Biological Process	GO:0090330	regulation of platelet aggregation	ISO	J:164563
Biological Process	GO:0048259	regulation of receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0047484	regulation of response to osmotic stress	IMP	J:240312
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	IDA	J:174964
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	IMP	J:174964
Biological Process	GO:0002026	regulation of the force of heart contraction	IMP	J:88510
Biological Process	GO:0032355	response to estradiol	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0000302	response to reactive oxygen species	ISO	J:155856
Biological Process	GO:0048863	stem cell differentiation	IDA	J:125386