GO Annotations Graph

• Symbol: Prkcz
• Name: protein kinase C, zeta
• ID: MGI:97602

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IEA	J:72245
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043274	phospholipase binding	ISO	J:155856
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:170429
Molecular Function	GO:0005515	protein binding	IPI	J:263374
Molecular Function	GO:0005515	protein binding	IPI	J:225407
Molecular Function	GO:0005515	protein binding	IPI	J:225409
Molecular Function	GO:0005515	protein binding	IPI	J:158132
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:87887
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:164563
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:170429
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0045179	apical cortex	IDA	J:99397
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:161201
Cellular Component	GO:0043203	axon hillock	IDA	J:158132
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:99397
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:99397
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:97223
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:99397
Cellular Component	GO:0005938	cell cortex	IDA	J:99397
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0031252	cell leading edge	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:84405
Cellular Component	GO:0005737	cytoplasm	IDA	J:63657
Cellular Component	GO:0005737	cytoplasm	IDA	J:87887
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005815	microtubule organizing center	IGI	J:158132
Cellular Component	GO:0005815	microtubule organizing center	IGI	J:158132
Cellular Component	GO:0035748	myelin sheath abaxonal region	IDA	J:159103
Cellular Component	GO:0005635	nuclear envelope	IDA	J:63657
Cellular Component	GO:0016363	nuclear matrix	IDA	J:63657
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:63657
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IDA	J:225407
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0031584	activation of phospholipase D activity	ISO	J:155856
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:155856
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0030010	establishment of cell polarity	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0051899	membrane depolarization	ISO	J:155856
Biological Process	GO:0060081	membrane hyperpolarization	ISO	J:155856
Biological Process	GO:0000226	microtubule cytoskeleton organization	IGI	J:158132
Biological Process	GO:0000226	microtubule cytoskeleton organization	IMP	J:98926
Biological Process	GO:0000226	microtubule cytoskeleton organization	IGI	J:158132
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0051346	negative regulation of hydrolase activity	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:1990138	neuron projection extension	IGI	J:158132
Biological Process	GO:1990138	neuron projection extension	IGI	J:158132
Biological Process	GO:1990138	neuron projection extension	IGI	J:158132
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:99860
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IMP	J:99860
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IMP	J:99860
Biological Process	GO:0032754	positive regulation of interleukin-5 production	IMP	J:99860
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0051222	positive regulation of protein transport	ISO	J:155856
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	IMP	J:99860
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IMP	J:99860
Biological Process	GO:0070528	protein kinase C signaling	ISO	J:155856
Biological Process	GO:0008104	protein localization	ISO	J:155856
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:107908
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:87887
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0047496	vesicle transport along microtubule	ISO	J:155856