GO Annotations Graph

• Symbol: Pklr
• Name: pyruvate kinase liver and red blood cell
• ID: MGI:97604

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0048029	monosaccharide binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030955	potassium ion binding	IEA	J:72247
Molecular Function	GO:0004743	pyruvate kinase activity	ISO	J:155856
Molecular Function	GO:0004743	pyruvate kinase activity	IBA	J:265628
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:6625
Molecular Function	GO:0004743	pyruvate kinase activity	IDA	J:92699
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:142120
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-164158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186509
Cellular Component	GO:0005829	cytosol	IDA	J:271616
Cellular Component	GO:0005886	plasma membrane	IDA	J:142120
Biological Process	GO:0006754	ATP biosynthetic process	ISO	J:155856
Biological Process	GO:0005975	carbohydrate metabolic process	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	IBA	J:265628
Biological Process	GO:0006096	glycolytic process	ISO	J:155856
Biological Process	GO:0006096	glycolytic process	IBA	J:265628
Biological Process	GO:0006096	glycolytic process	IDA	J:6625
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0042866	pyruvate biosynthetic process	ISO	J:155856
Biological Process	GO:0033198	response to ATP	ISO	J:155856
Biological Process	GO:0051591	response to cAMP	ISO	J:155856
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0010226	response to lithium ion	ISO	J:155856
Biological Process	GO:0051707	response to other organism	IMP	J:86735