GO Annotations Graph

• Symbol: Serpine1
• Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
• ID: MGI:97608

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:94483
Molecular Function	GO:0005515	protein binding	IPI	J:36876
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IDA	J:94483
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0042583	chromaffin granule	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	NAS	J:320135
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:1904090	peptidase inhibitor complex	ISO	J:164563
Cellular Component	GO:0097180	serine protease inhibitor complex	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:220437
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:155856
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:176254
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:144462
Biological Process	GO:0097187	dentinogenesis	ISO	J:164563
Biological Process	GO:0008585	female gonad development	ISO	J:155856
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0010951	negative regulation of endopeptidase activity	ISO	J:164563
Biological Process	GO:0010951	negative regulation of endopeptidase activity	ISO	J:155856
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IBA	J:265628
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0051918	negative regulation of fibrinolysis	ISO	J:164563
Biological Process	GO:0051918	negative regulation of fibrinolysis	NAS	J:320118
Biological Process	GO:0051918	negative regulation of fibrinolysis	NAS	J:320134
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:0010757	negative regulation of plasminogen activation	ISO	J:164563
Biological Process	GO:0010757	negative regulation of plasminogen activation	IMP	J:155899
Biological Process	GO:0010757	negative regulation of plasminogen activation	NAS	J:320118
Biological Process	GO:0010757	negative regulation of plasminogen activation	IBA	J:265628
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:2000098	negative regulation of smooth muscle cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0061044	negative regulation of vascular wound healing	ISO	J:164563
Biological Process	GO:0061044	negative regulation of vascular wound healing	IMP	J:44500
Biological Process	GO:0061044	negative regulation of vascular wound healing	IBA	J:265628
Biological Process	GO:0001890	placenta development	IMP	J:220437
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:140088
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:220437
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0090280	positive regulation of calcium ion import	ISO	J:155856
Biological Process	GO:0050820	positive regulation of coagulation	ISO	J:155856
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:1905043	positive regulation of epithelium regeneration	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0051549	positive regulation of keratinocyte migration	ISO	J:155856
Biological Process	GO:0035491	positive regulation of leukotriene production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:1901331	positive regulation of odontoblast differentiation	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0045765	regulation of angiogenesis	IDA	J:74281
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:133497
Biological Process	GO:0010469	regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0090399	replicative senescence	ISO	J:164563