GO Annotations Graph

• Symbol: Plcb1
• Name: phospholipase C, beta 1
• ID: MGI:97613

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	IDA	J:169993
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0099103	channel activator activity	IDA	J:169993
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IDA	J:169993
Molecular Function	GO:0005521	lamin binding	IPI	J:169987
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:155856
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IBA	J:265628
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:169991
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:169993
Cellular Component	GO:0000785	chromatin	IDA	J:169987
Cellular Component	GO:0005737	cytoplasm	IDA	J:169907
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:169990
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:117528
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:124819
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:124819
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:124819
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:103748
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:103748
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:103748
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0016607	nuclear speck	IDA	J:169991
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:169790
Cellular Component	GO:0005634	nucleus	IDA	J:169809
Cellular Component	GO:0005634	nucleus	NAS	J:169993
Cellular Component	GO:0005634	nucleus	IDA	J:169907
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:169990
Cellular Component	GO:0005634	nucleus	IDA	J:169795
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-445860
Cellular Component	GO:0005886	plasma membrane	ISO	J:328022
Cellular Component	GO:0005886	plasma membrane	ISO	J:328022
Cellular Component	GO:0098794	postsynapse	IDA	J:103748
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:143242
Cellular Component	GO:0099524	postsynaptic cytosol	IEP	J:143242
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:143242
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:143242
Cellular Component	GO:0032991	protein-containing complex	IDA	J:240063
Biological Process	GO:0060466	activation of meiosis involved in egg activation	IDA	J:169795
Biological Process	GO:0007420	brain development	NAS	J:169989
Biological Process	GO:0007155	cell adhesion	IC	J:169907
Biological Process	GO:1902618	cellular response to fluoride	ISO	J:155856
Biological Process	GO:1905631	cellular response to glyceraldehyde	ISO	J:155856
Biological Process	GO:1904637	cellular response to ionomycin	ISO	J:155856
Biological Process	GO:1904117	cellular response to vasopressin	ISO	J:155856
Biological Process	GO:0021987	cerebral cortex development	IMP	J:109291
Biological Process	GO:0030218	erythrocyte differentiation	TAS	J:169984
Biological Process	GO:0045444	fat cell differentiation	IDA	J:169980
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	IMP	J:43077
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	IDA	J:169987
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	NAS	J:169990
Biological Process	GO:0007215	glutamate receptor signaling pathway	IMP	J:109291
Biological Process	GO:0032957	inositol trisphosphate metabolic process	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	TAS	J:169984
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:169815
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:289428
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:289428
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:232958
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:289428
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:289428
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:232958
Biological Process	GO:0016042	lipid catabolic process	IEA	J:72247
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0030225	macrophage differentiation	NAS	J:155351
Biological Process	GO:0007613	memory	IMP	J:169989
Biological Process	GO:0007613	memory	IBA	J:265628
Biological Process	GO:0006397	mRNA processing	TAS	J:170753
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:169803
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:169991
Biological Process	GO:2000438	negative regulation of monocyte extravasation	IDA	J:167110
Biological Process	GO:0001556	oocyte maturation	NAS	J:169990
Biological Process	GO:0031161	phosphatidylinositol catabolic process	ISO	J:155856
Biological Process	GO:0046488	phosphatidylinositol metabolic process	ISO	J:164563
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IBA	J:265628
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP	J:289428
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI	J:58572
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:289428
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:232958
Biological Process	GO:2000344	positive regulation of acrosome reaction	IMP	J:70264
Biological Process	GO:2000560	positive regulation of CD24 production	IDA	J:169907
Biological Process	GO:0048639	positive regulation of developmental growth	IMP	J:93076
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:169907
Biological Process	GO:0040019	positive regulation of embryonic development	IMP	J:70264
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IDA	J:169809
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:289428
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:289428
Biological Process	GO:0032024	positive regulation of insulin secretion	IGI	J:58572
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:232958
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:169995
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IDA	J:169790
Biological Process	GO:0032417	positive regulation of sodium:proton antiporter activity	NAS	J:169906
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:103748
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:103748
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	EXP	J:103748
Biological Process	GO:0051726	regulation of cell cycle	IEA	J:72247
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	IMP	J:242176
Biological Process	GO:0080154	regulation of fertilization	IMP	J:70264
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:169989
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA	J:124819
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	IMP	J:124819
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA	J:124819
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0034284	response to monosaccharide	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0007165	signal transduction	TAS	J:169984