GO Annotations Graph

• Symbol: Plcg2
• Name: phospholipase C, gamma 2
• ID: MGI:97616

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0034480	phosphatidylcholine phospholipase C activity	TAS	Reactome:R-MMU-9682158
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:155856
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	EXP	J:266152
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IBA	J:265628
Molecular Function	GO:0004629	phospholipase C activity	TAS	J:75316
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	IPI	J:76319
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:200363
Molecular Function	GO:0005515	protein binding	IPI	J:232061
Molecular Function	GO:0005515	protein binding	IPI	J:114724
Molecular Function	GO:0005515	protein binding	IPI	J:237276
Molecular Function	GO:0005515	protein binding	IPI	J:237276
Molecular Function	GO:0005515	protein binding	IPI	J:129312
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IMP	J:63744
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5607754
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027429
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027436
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9032476
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0032237	activation of store-operated calcium channel activity	IMP	J:95865
Biological Process	GO:0061760	antifungal innate immune response	IMP	J:178744
Biological Process	GO:0030183	B cell differentiation	IMP	J:63744
Biological Process	GO:0050853	B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IMP	J:63744
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0001775	cell activation	IMP	J:148372
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:1990858	cellular response to lectin	IMP	J:148372
Biological Process	GO:0071396	cellular response to lipid	ISO	J:164563
Biological Process	GO:0002316	follicular B cell differentiation	IMP	J:86373
Biological Process	GO:0032959	inositol trisphosphate biosynthetic process	IDA	J:38367
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:148372
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:178744
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:178744
Biological Process	GO:0043069	negative regulation of programmed cell death	IMP	J:86373
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IBA	J:265628
Biological Process	GO:0009395	phospholipid catabolic process	IEA	J:72247
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IMP	J:148372
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:148372
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:148372
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:148372
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	IMP	J:178744
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:178744
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:148372
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:178744
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:148372
Biological Process	GO:0032747	positive regulation of interleukin-23 production	IMP	J:148372
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:178744
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:148372
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:178744
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:178744
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:148372
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:148372
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:178744
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:178744
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	IMP	J:178744
Biological Process	GO:0002092	positive regulation of receptor internalization	IMP	J:178826
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:148372
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:178744
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:178826
Biological Process	GO:0012501	programmed cell death	IMP	J:86373
Biological Process	GO:0070884	regulation of calcineurin-NFAT signaling cascade	IMP	J:148372
Biological Process	GO:0010468	regulation of gene expression	IMP	J:86373
Biological Process	GO:0010468	regulation of gene expression	IMP	J:86373
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:178744
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:148372
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:63744
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0033198	response to ATP	ISO	J:155856
Biological Process	GO:0048678	response to axon injury	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:38367
Biological Process	GO:0032026	response to magnesium ion	ISO	J:155856
Biological Process	GO:0001878	response to yeast	IMP	J:178744
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	IMP	J:178744
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	IMP	J:148372
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:96628
Biological Process	GO:0002224	toll-like receptor signaling pathway	IMP	J:148372