GO Annotations Graph

• Symbol: Pln
• Name: phospholamban
• ID: MGI:97622

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042030	ATPase inhibitor activity	ISO	J:164563
Molecular Function	GO:0042030	ATPase inhibitor activity	ISO	J:155856
Molecular Function	GO:0042030	ATPase inhibitor activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:274777
Molecular Function	GO:0005515	protein binding	IPI	J:228307
Molecular Function	GO:0005515	protein binding	IPI	J:296128
Molecular Function	GO:0005515	protein binding	IPI	J:260257
Molecular Function	GO:0005515	protein binding	IPI	J:91410
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:274777
Cellular Component	GO:0090534	calcium ion-transporting ATPase complex	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:272982
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:260257
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:38400
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:229305
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0001675	acrosome assembly	IDA	J:272982
Biological Process	GO:0086023	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	IMP	J:59503
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0048738	cardiac muscle tissue development	IGI	J:58299
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IDA	J:272982
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IGI	J:58299
Biological Process	GO:0046716	muscle cell cellular homeostasis	IGI	J:58299
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	ISO	J:164563
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	ISO	J:164563
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	IMP	J:274777
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	IBA	J:265628
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA	J:260257
Biological Process	GO:1901877	negative regulation of calcium ion binding	ISO	J:164563
Biological Process	GO:1901877	negative regulation of calcium ion binding	IDA	J:260257
Biological Process	GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum	IMP	J:274777
Biological Process	GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum	IBA	J:265628
Biological Process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0051926	negative regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0045822	negative regulation of heart contraction	IMP	J:39745
Biological Process	GO:0045822	negative regulation of heart contraction	IGI	J:58299
Biological Process	GO:0010459	negative regulation of heart rate	ISO	J:164563
Biological Process	GO:0010459	negative regulation of heart rate	IBA	J:265628
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:216917
Biological Process	GO:1901894	regulation of ATPase-coupled calcium transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0090279	regulation of calcium ion import	IMP	J:111974
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IMP	J:111974
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP	J:35553
Biological Process	GO:0008016	regulation of heart contraction	ISO	J:164563
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:35553
Biological Process	GO:1901077	regulation of relaxation of muscle	IMP	J:53734
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:112004
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	IMP	J:59801
Biological Process	GO:0002026	regulation of the force of heart contraction	IGI	J:58299
Biological Process	GO:0002026	regulation of the force of heart contraction	IGI	J:58299
Biological Process	GO:0002026	regulation of the force of heart contraction	IMP	J:112004
Biological Process	GO:0086092	regulation of the force of heart contraction by cardiac conduction	IMP	J:59967
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0010043	response to zinc ion	ISO	J:155856