GO Annotations Graph

• Symbol: Prrx1
• Name: paired related homeobox 1
• ID: MGI:97712

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:93586
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:196061
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA	J:72247
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:179858
Molecular Function	GO:0071837	HMG box domain binding	IPI	J:175179
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:179858
Molecular Function	GO:0016251	RNA polymerase II general transcription initiation factor activity	IDA	J:286856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:196061
Cellular Component	GO:0005634	nucleus	IDA	J:73653
Biological Process	GO:0048844	artery morphogenesis	IGI	J:60507
Biological Process	GO:0048844	artery morphogenesis	IMP	J:60507
Biological Process	GO:0051216	cartilage development	IMP	J:25649
Biological Process	GO:0051216	cartilage development	IMP	J:25649
Biological Process	GO:0051216	cartilage development	IMP	J:25649
Biological Process	GO:0051216	cartilage development	IGI	J:51596
Biological Process	GO:0051216	cartilage development	IMP	J:25649
Biological Process	GO:0051216	cartilage development	IMP	J:25649
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:50488
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:25649
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:52212
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:50488
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IMP	J:25649
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IGI	J:50488
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IGI	J:51596
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IGI	J:71035
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:50488
Biological Process	GO:0010463	mesenchymal cell proliferation	IGI	J:71035
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:25649
Biological Process	GO:0042474	middle ear morphogenesis	IGI	J:50488
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:179858
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0048664	neuron fate determination	IDA	J:196061
Biological Process	GO:0097150	neuronal stem cell population maintenance	IDA	J:196061
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IGI	J:71035
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	IGI	J:71035
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IGI	J:71035
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:196061
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0070570	regulation of neuron projection regeneration	IMP	J:196061
Biological Process	GO:0060021	roof of mouth development	IMP	J:25649
Biological Process	GO:0007224	smoothened signaling pathway	IGI	J:71035
Biological Process	GO:0072089	stem cell proliferation	IGI	J:71035