GO Annotations Graph

• Symbol: Pomc
• Name: pro-opiomelanocortin-alpha
• ID: MGI:97742

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	IDA	J:94140
Molecular Function	GO:0005515	protein binding	IPI	J:102191
Molecular Function	GO:0005515	protein binding	IPI	J:102191
Molecular Function	GO:0005515	protein binding	IPI	J:102191
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0070996	type 1 melanocortin receptor binding	ISO	J:164563
Molecular Function	GO:0031781	type 3 melanocortin receptor binding	ISO	J:164563
Molecular Function	GO:0031782	type 4 melanocortin receptor binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:136893
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9623076
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:102191
Cellular Component	GO:0005782	peroxisomal matrix	ISO	J:164563
Cellular Component	GO:0030141	secretory granule	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	IDA	J:15586
Cellular Component	GO:0030141	secretory granule	IDA	J:102191
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:306585
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0033059	cellular pigmentation	ISO	J:164563
Biological Process	GO:0006091	generation of precursor metabolites and energy	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:179468
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0035821	modulation of process of another organism	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	IEA	J:60000
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	IDA	J:306585
Biological Process	GO:0070965	positive regulation of neutrophil mediated killing of fungus	ISO	J:164563
Biological Process	GO:0140668	positive regulation of oxytocin production	IDA	J:306585
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032098	regulation of appetite	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IGI	J:102928
Biological Process	GO:0008217	regulation of blood pressure	IGI	J:102928
Biological Process	GO:2000852	regulation of corticosterone secretion	IBA	J:265628
Biological Process	GO:2000852	regulation of corticosterone secretion	IMP	J:179468
Biological Process	GO:0070873	regulation of glycogen metabolic process	IMP	J:179468
Biological Process	GO:1990680	response to melanocyte-stimulating hormone	IDA	J:306585
Biological Process	GO:0007165	signal transduction	ISO	J:164563