GO Annotations Graph

• Symbol: Prl
• Name: prolactin
• ID: MGI:97762

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	TAS	J:78881
Molecular Function	GO:0005148	prolactin receptor binding	IBA	J:265628
Molecular Function	GO:0005148	prolactin receptor binding	ISO	J:73065
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:41858
Cellular Component	GO:0030141	secretory granule	IDA	J:102191
Biological Process	GO:0008283	cell population proliferation	IGI	J:41857
Biological Process	GO:0008283	cell population proliferation	IGI	J:41857
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:41857
Biological Process	GO:0007565	female pregnancy	IBA	J:265628
Biological Process	GO:0007595	lactation	IEA	J:60000
Biological Process	GO:0030879	mammary gland development	IBA	J:265628
Biological Process	GO:0030879	mammary gland development	IGI	J:137356
Biological Process	GO:0042711	maternal behavior	IGI	J:192857
Biological Process	GO:0042711	maternal behavior	IGI	J:192857
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:41857
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IGI	J:41857
Biological Process	GO:1903489	positive regulation of lactation	IBA	J:265628
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IGI	J:120010
Biological Process	GO:0030278	regulation of ossification	ISO	J:155856
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	IDA	J:78881
Biological Process	GO:0031667	response to nutrient levels	IBA	J:265628