GO Annotations Graph

• Symbol: Prlr
• Name: prolactin receptor
• ID: MGI:97763

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	IBA	J:265628
Molecular Function	GO:0004925	prolactin receptor activity	ISO	J:155856
Molecular Function	GO:0004925	prolactin receptor activity	ISO	J:164563
Molecular Function	GO:0004925	prolactin receptor activity	IMP	J:72801
Molecular Function	GO:0004925	prolactin receptor activity	IDA	J:7060
Molecular Function	GO:0005515	protein binding	IPI	J:158376
Molecular Function	GO:0005515	protein binding	IPI	J:158376
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0042976	activation of Janus kinase activity	ISO	J:164563
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0007595	lactation	IGI	J:70408
Biological Process	GO:0007595	lactation	IMP	J:72801
Biological Process	GO:0007595	lactation	IMP	J:108377
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:108377
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:70408
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:108377
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IGI	J:108377
Biological Process	GO:0061180	mammary gland epithelium development	IMP	J:76874
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:132155
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:155856
Biological Process	GO:0038161	prolactin signaling pathway	IEA	J:72247
Biological Process	GO:0060736	prostate gland growth	IMP	J:84352
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IMP	J:108377
Biological Process	GO:0030155	regulation of cell adhesion	IMP	J:72801
Biological Process	GO:0030856	regulation of epithelial cell differentiation	IMP	J:72801
Biological Process	GO:0009617	response to bacterium	IEP	J:190322