GO Annotations Graph

• Symbol: Prnp
• Name: prion protein
• ID: MGI:97769

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0001540	amyloid-beta binding	IDA	J:145956
Molecular Function	GO:0001540	amyloid-beta binding	TAS	J:190064
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	IDA	J:122497
Molecular Function	GO:0043008	ATP-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:0005507	copper ion binding	IDA	J:82408
Molecular Function	GO:1903135	cupric ion binding	IMP	J:240271
Molecular Function	GO:1903136	cuprous ion binding	ISO	J:164563
Molecular Function	GO:0005539	glycosaminoglycan binding	IDA	J:122497
Molecular Function	GO:0042802	identical protein binding	IPI	J:245380
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:200371
Molecular Function	GO:0042802	identical protein binding	IPI	J:284982
Molecular Function	GO:0042802	identical protein binding	IPI	J:248242
Molecular Function	GO:0042802	identical protein binding	IPI	J:201296
Molecular Function	GO:0042802	identical protein binding	IPI	J:200924
Molecular Function	GO:0042802	identical protein binding	IPI	J:245333
Molecular Function	GO:0005521	lamin binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IDA	J:326234
Molecular Function	GO:0046872	metal ion binding	EXP	J:326234
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	EXP	J:325955
Molecular Function	GO:0060090	molecular adaptor activity	IPI	J:258023
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	IDA	J:325958
Molecular Function	GO:0140693	molecular condensate scaffold activity	EXP	J:325958
Molecular Function	GO:0002020	protease binding	IPI	J:122497
Molecular Function	GO:0005515	protein binding	IPI	J:201297
Molecular Function	GO:0005515	protein binding	IPI	J:145956
Molecular Function	GO:0005515	protein binding	IPI	J:201317
Molecular Function	GO:0005515	protein binding	IPI	J:145956
Molecular Function	GO:0005515	protein binding	IPI	J:188385
Molecular Function	GO:0005515	protein binding	IPI	J:258023
Molecular Function	GO:0005515	protein binding	IPI	J:236616
Molecular Function	GO:0005515	protein binding	IPI	J:327045
Molecular Function	GO:0005515	protein binding	IPI	J:157527
Molecular Function	GO:0005515	protein binding	IPI	J:251563
Molecular Function	GO:0005515	protein binding	IPI	J:207227
Molecular Function	GO:0005515	protein binding	IPI	J:72874
Molecular Function	GO:0005515	protein binding	IPI	J:72874
Molecular Function	GO:0005515	protein binding	IPI	J:72874
Molecular Function	GO:0140311	protein sequestering activity	IDA	J:171988
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:145956
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IMP	J:145956
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0015631	tubulin binding	ISO	J:164563
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	ISO	J:164563
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	IPI	J:201741
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:102391
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:145956
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:75094
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:75094
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:207227
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	IMP	J:122497
Cellular Component	GO:0045121	membrane raft	IDA	J:85358
Cellular Component	GO:0045121	membrane raft	TAS	J:77769
Cellular Component	GO:0045121	membrane raft	IDA	J:53127
Cellular Component	GO:0045121	membrane raft	ISO	J:102391
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:163149
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-420384
Cellular Component	GO:0005886	plasma membrane	ISO	J:102391
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	IDA	J:91817
Biological Process	GO:0032147	activation of protein kinase activity	IGI	J:240258
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	IGI	J:201741
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	ISO	J:164563
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:201741
Biological Process	GO:0071280	cellular response to copper ion	ISO	J:102391
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:102391
Biological Process	GO:0006878	intracellular copper ion homeostasis	TAS	J:75094
Biological Process	GO:0007611	learning or memory	IGI	J:160557
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	IMP	J:169942
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	IGI	J:122497
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	IGI	J:122497
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:98763
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:169942
Biological Process	GO:0043086	negative regulation of catalytic activity	ISO	J:155856
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	IGI	J:201741
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	IGI	J:190064
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IMP	J:169942
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:169942
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IMP	J:169942
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:169942
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	IMP	J:169942
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:169942
Biological Process	GO:1990535	neuron projection maintenance	IGI	J:160557
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	TAS	J:78772
Biological Process	GO:0010942	positive regulation of cell death	IGI	J:240258
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	IGI	J:190064
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:190064
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	IMP	J:240258
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IGI	J:190064
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	IEA	J:72247
Biological Process	GO:1905664	regulation of calcium ion import across plasma membrane	IGI	J:190064
Biological Process	GO:1900449	regulation of glutamate receptor signaling pathway	IGI	J:190064
Biological Process	GO:1902938	regulation of intracellular calcium activated chloride channel activity	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IGI	J:190064
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	IGI	J:207227
Biological Process	GO:0032880	regulation of protein localization	IMP	J:53127
Biological Process	GO:1904645	response to amyloid-beta	IGI	J:190064
Biological Process	GO:0046686	response to cadmium ion	ISO	J:155856
Biological Process	GO:0046688	response to copper ion	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IDA	J:82408