GO Annotations Graph

• Symbol: Pth1r
• Name: parathyroid hormone 1 receptor
• ID: MGI:97801

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004991	parathyroid hormone receptor activity	ISO	J:155856
Molecular Function	GO:0004991	parathyroid hormone receptor activity	ISO	J:164563
Molecular Function	GO:0004991	parathyroid hormone receptor activity	IBA	J:265628
Molecular Function	GO:0004991	parathyroid hormone receptor activity	IMP	J:108801
Molecular Function	GO:0004991	parathyroid hormone receptor activity	TAS	J:72784
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:60156
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:108801
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030282	bone mineralization	IMP	J:72784
Biological Process	GO:0030282	bone mineralization	IMP	J:108801
Biological Process	GO:0045453	bone resorption	IMP	J:108801
Biological Process	GO:0048469	cell maturation	IMP	J:108984
Biological Process	GO:0048469	cell maturation	IMP	J:108984
Biological Process	GO:0008283	cell population proliferation	IGI	J:107230
Biological Process	GO:0008283	cell population proliferation	IGI	J:107230
Biological Process	GO:0008283	cell population proliferation	IMP	J:108984
Biological Process	GO:0008283	cell population proliferation	IMP	J:108984
Biological Process	GO:0008283	cell population proliferation	IMP	J:108984
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:107230
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:108801
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO	J:155856
Biological Process	GO:0001701	in utero embryonic development	IMP	J:240631
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:108801
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:108984
Biological Process	GO:0001503	ossification	IMP	J:108984
Biological Process	GO:0002076	osteoblast development	IMP	J:108801
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:108984
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:107230
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0060732	positive regulation of inositol phosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0001501	skeletal system development	IMP	J:72784
Biological Process	GO:0001501	skeletal system development	IMP	J:34604