GO Annotations Graph

• Symbol: Ptn
• Name: pleiotrophin
• ID: MGI:97804

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030246	carbohydrate binding	ISO	J:164563
Molecular Function	GO:0035374	chondroitin sulfate binding	ISO	J:164563
Molecular Function	GO:0035373	chondroitin sulfate proteoglycan binding	ISO	J:155856
Molecular Function	GO:0005539	glycosaminoglycan binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:1904399	heparan sulfate binding	ISO	J:155856
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004864	protein phosphatase inhibitor activity	ISO	J:164563
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:155856
Molecular Function	GO:0045545	syndecan binding	ISO	J:155856
Molecular Function	GO:0038085	vascular endothelial growth factor binding	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	TAS	J:77465
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IDA	J:273520
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:77465
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:77465
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:77465
Biological Process	GO:0030282	bone mineralization	IDA	J:80035
Biological Process	GO:0046697	decidualization	IMP	J:273547
Biological Process	GO:0140059	dendrite arborization	IMP	J:281259
Biological Process	GO:0031104	dendrite regeneration	ISO	J:155856
Biological Process	GO:0044849	estrous cycle	IMP	J:123392
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007612	learning	IMP	J:218928
Biological Process	GO:0007612	learning	IMP	J:77465
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	IMP	J:102069
Biological Process	GO:0007613	memory	IMP	J:218928
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:77465
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:77465
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:77465
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0060253	negative regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IMP	J:77465
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IMP	J:70253
Biological Process	GO:0045837	negative regulation of membrane potential	ISO	J:155856
Biological Process	GO:0072201	negative regulation of mesenchymal cell proliferation	ISO	J:155856
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	IMP	J:91002
Biological Process	GO:1904397	negative regulation of neuromuscular junction development	ISO	J:155856
Biological Process	GO:0048477	oogenesis	IMP	J:123392
Biological Process	GO:0001503	ossification	IDA	J:80035
Biological Process	GO:0043932	ossification involved in bone remodeling	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0048680	positive regulation of axon regeneration	ISO	J:155856
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:273520
Biological Process	GO:0045597	positive regulation of cell differentiation	IMP	J:273547
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ISO	J:155856
Biological Process	GO:1900006	positive regulation of dendrite development	IMP	J:281259
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	IMP	J:102069
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	IMP	J:102069
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:164563
Biological Process	GO:0045778	positive regulation of ossification	ISO	J:155856
Biological Process	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering	ISO	J:155856
Biological Process	GO:2000738	positive regulation of stem cell differentiation	IMP	J:91002
Biological Process	GO:0043113	receptor clustering	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:155856
Biological Process	GO:1903706	regulation of hemopoiesis	IMP	J:177072
Biological Process	GO:0031641	regulation of myelination	IMP	J:236151
Biological Process	GO:2000036	regulation of stem cell population maintenance	IMP	J:177072
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:70253
Biological Process	GO:0010996	response to auditory stimulus	IMP	J:110520
Biological Process	GO:0060221	retinal rod cell differentiation	ISO	J:155856
Biological Process	GO:0042246	tissue regeneration	IMP	J:102069